53848-17-2

Basic information

• Product Name: 2-BROMO-6-METHYLANILINE
• Synonyms: 2-BROMO-6-METHYLANILINE;2-broMo-6-MethylbenzenaMine;2-BroMo-6-Methylaniline, 95+%;2-Bromo-6-methylaniline 95%
• CAS NO: 53848-17-2
• Molecular Formula: C₇H₈BrN
• Molecular Weight: 186.05
• Product Categories: Amines;C7;Nitrogen Compounds;NULL
• Mol File: 53848-17-2.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 105-107 °C205 mm Hg(lit.)
• Flash Point: 215 °F
• Appearance: /
• Density: 1.4780 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.0319mmHg at 25°C
• Refractive Index: n20/D 1.6030(lit.)
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 2.39±0.10(Predicted)
• CAS DataBase Reference: 2-BROMO-6-METHYLANILINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BROMO-6-METHYLANILINE(53848-17-2)
• EPA Substance Registry System: 2-BROMO-6-METHYLANILINE(53848-17-2)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 53848-17-2(Hazardous Substances Data)

Usage

Uses

2-Bromo-6-methylaniline can be used as a reactant to synthesize: Alkyl substituted bromoindazole building blocks by Pd-catalyzed Suzuki coupling reaction with various vinyl boronic acids.Difluoropyridoindole via Pd-catalyzed intramolecular Heck reaction with difluoropiperidinone. 4-Methyl-N-phenyl-1H-benzo[d]imidazol-2-amine by one-pot Cu-catalyzed domino C-N cross-coupling reaction with iodobenzene and thiourea.

InChI:InChI=1/C7H8BrN/c1-5-3-2-4-6(8)7(5)9/h2-4H,9H2,1H3

Upstream product

• 958990-53-9 6-amino-5-bromo-toluene-3-sulfonic acid 
• 7732-18-5 water 
• 7647-01-0 hydrogenchloride 
• 52414-97-8 1-bromo-3-methyl-2-nitro-benzene 
• 95-53-4 o-toluidine 
• 601-87-6 3-methyl-2-nitroaniline 
• 98-33-9 2-aminotoluene-5-sulfonic acid 
• 88-72-2 1-methyl-2-nitrobenzene 

Downstream Products

• 845751-60-2 (2-bromo-6-methylphenyl)[(1,1-dimethylethyl)thio]diazene 
• 1427000-79-0 4,5,6,7-tetrahydro-3-(2-bromo-6-methylphenyl)-(3H)-benzothiazole-2-thione 
• 1427000-80-3 4,5,6,7-tetrahydro-3-[2-(3,5-ditert-butylphenyl)-6-methylphenyl]-(3H)-benzothiazole-2-thione 
• 1427000-81-4 3-[2-(3,5-ditert-butylphenyl)-6-methylphenyl]-4,5,6,7-tetrahydrobenzothiazolium chloride 
• 1451051-76-5 C₉H₁₀BrNO₂ 
• 210536-43-9 6-methyl-2-vinylaniline 
• 701910-15-8 7-(2,4-dichloro-phenyl)-2-methyl-2H-indazole 
• 701910-21-6 7-(2,4-dichloro-phenyl)-2-methyl-2H-indazol-3-ylamine 
• 845751-92-0 C₈H₆BrClN₂O₂S 

Relevant articles and documents

Novel cyclic bicarbodiimide compound and preparation method of novel cyclic bicarbodiimide compound

The invention relates to a novel cyclic bicarbodiimide compound (I) and a preparation method of the novel cyclic bicarbodiimide compound. Compared with monocarbodiimide, the novel cyclic bicarbodiimide compound has a higher molecular weight and a higher melting point; the disadvantage that the monocarbodiimide is easily transferred outward from compounds including polyester, polyurethane and like at high temperature is overcome; the anti-hydrolytic property of a material is improved; meanwhile, the defects that an existing bicarbodiimide compound is easily irregularly curled, easily forms a rubber state at room temperature and is not easy to crystallize and purify are overcome; the anti-hydrolytic effect is good and the bicarbodiimide compound has a good anti-hydrolytic property; the service life of a polyester material is improved; the bicarbodiimide compound can be used as an anti-hydrolytic stabilizer and is used for polyurethane and polyester elastomers, and especially can be used for photovoltaic industry, biodegradable materials and the like. The formula (I) is shown in the description.

Selective oxidation of sulfides and oxidative bromination of organic substrates catalyzed by polymer anchored Cu(II) complex

A new polymer-anchored Cu(II) complex has been synthesized and characterized. The catalytic performance of the complex has been tested for the oxidation of sulfides and in oxidative bromination reaction with hydrogen peroxide as the oxidant. Sulfides have been selectively oxidized to the corresponding sulfoxides in excellent yields and in the presence of KBr as the bromine source, organic substrates have been selectively converted to mono bromo substituted compounds using polymer-anchored Cu(II) catalyst. This catalyst showed excellent catalytic activity, high selectivity, and recyclability. The polymer-anchored Cu(II) catalyst could be easily recovered by filtration and reused more than five times without appreciable loss of its initial activity.

GABANERGIC MODULATORS

This invention relates to the use of compounds of benzoindazole derivatives salts and solvates thereof for the preparation of a medicament for modulating alpha2 subtype GABA A receptors. The invention further relates to novel heterocyclic compounds and pharmaceutical compositions containing said compounds. In addition the invention relates to the use of compounds of formula (I) salts and solvates thereof for the preparation of a medicament for the treatment of depression, an anxiety disorder, a psychiatric disorder, a learning or cognitive disorder, a sleep disorder, a convulsive or seizure disorder or pain.