tert-butyl (1S,2S,3S,5R)-3-(dibenzylamino)-6,6-dimethylbicyclo[3.1.1]heptane-2-carboxylate

Base Information

• Chemical Name: tert-butyl (1S,2S,3S,5R)-3-(dibenzylamino)-6,6-dimethylbicyclo[3.1.1]heptane-2-carboxylate
• CAS No.: 1261243-55-3
• Molecular Formula: C₂₈H₃₇NO₂
• Molecular Weight: 419.607

Synonyms:tert-butyl (1S,2S,3S,5R)-3-(dibenzylamino)-6,6-dimethylbicyclo[3.1.1]heptane-2-carboxylate

Chemical Property of tert-butyl (1S,2S,3S,5R)-3-(dibenzylamino)-6,6-dimethylbicyclo[3.1.1]heptane-2-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl (1S,2S,3S,5R)-3-(dibenzylamino)-6,6-dimethylbicyclo[3.1.1]heptane-2-carboxylate

There total 1 articles about tert-butyl (1S,2S,3S,5R)-3-(dibenzylamino)-6,6-dimethylbicyclo[3.1.1]heptane-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

(-)-(1R,5S)-tert-butyl 6,6-dimethylbicyclo[3.1.1]hept-2-ene-2-carboxylate (105430-75-9) + dibenzylamine (103-49-1) → tert-butyl (1S,2S,3S,5R)-3-(dibenzylamino)-6,6-dimethylbicyclo[3.1.1]heptane-2-carboxylate (1261243-55-3)

Guidance literature:

dibenzylamine; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h; Inert atmosphere;

(-)-(1R,5S)-tert-butyl 6,6-dimethylbicyclo[3.1.1]hept-2-ene-2-carboxylate; In tetrahydrofuran; hexane; at -78 ℃; for 6h; Inert atmosphere;

With water; ammonium chloride; In tetrahydrofuran; hexane; at -78 - 20 ℃; stereospecific reaction;

DOI:10.1016/j.tetasy.2010.09.009

Reference yield: 89.0%

tert-butyl (1S,2S,3S,5R)-3-(dibenzylamino)-6,6-dimethylbicyclo[3.1.1]heptane-2-carboxylate (1261243-55-3) → tert-butyl (1S,2S,3S,5R)-3-benzylamino-6,6-dimethylbicyclo[3.1.1]heptane-2-carboxylate (1261243-59-7)

Guidance literature:

With 10% palladium on activated carbon; hydrogen; acetic acid; at 20 ℃; for 2h; under 760.051 Torr;

DOI:10.1016/j.tetasy.2010.09.009

Reference yield: 71.0%

tert-butyl (1S,2S,3S,5R)-3-(dibenzylamino)-6,6-dimethylbicyclo[3.1.1]heptane-2-carboxylate (1261243-55-3) → (1S,2S,3S,5R)-3-(dibenzylamino)-6,6-dimethylbicyclo[3.1.1]heptane-2-carboxylic acid hydrochloride (1261243-63-3)

Guidance literature:

With hydrogenchloride; In diethyl ether; water; at 20 ℃; for 24h;

DOI:10.1016/j.tetasy.2010.09.009

upstream raw materials:

(-)-(1R,5S)-tert-butyl 6,6-dimethylbicyclo[3.1.1]hept-2-ene-2-carboxylate

dibenzylamine

Downstream raw materials:

tert-butyl (1S,2S,3S,5R)-3-benzylamino-6,6-dimethylbicyclo[3.1.1]heptane-2-carboxylate

(1S,2S,3S,5R)-3-(dibenzylamino)-6,6-dimethylbicyclo[3.1.1]heptane-2-carboxylic acid hydrochloride

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1261243-55-3 tert-butyl (1S,2S,3S,5R)-3-(dibenzylamino)-6,6-dimethylbicyclo[3.1.1]heptane-2-carboxylate

Send

Send

Metric Ton KG G Pound L ML

Send

Send