tert-butyl (1S,2S,3S,5R)-3-benzylamino-6,6-dimethylbicyclo[3.1.1]heptane-2-carboxylate

Base Information

• Chemical Name: tert-butyl (1S,2S,3S,5R)-3-benzylamino-6,6-dimethylbicyclo[3.1.1]heptane-2-carboxylate
• CAS No.: 1261243-59-7
• Molecular Formula: C₂₁H₃₁NO₂
• Molecular Weight: 329.483
• Mol file: 1261243-59-7.mol

Synonyms:tert-butyl (1S,2S,3S,5R)-3-benzylamino-6,6-dimethylbicyclo[3.1.1]heptane-2-carboxylate

Chemical Property of tert-butyl (1S,2S,3S,5R)-3-benzylamino-6,6-dimethylbicyclo[3.1.1]heptane-2-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl (1S,2S,3S,5R)-3-benzylamino-6,6-dimethylbicyclo[3.1.1]heptane-2-carboxylate

There total 1 articles about tert-butyl (1S,2S,3S,5R)-3-benzylamino-6,6-dimethylbicyclo[3.1.1]heptane-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

tert-butyl (1S,2S,3S,5R)-3-(dibenzylamino)-6,6-dimethylbicyclo[3.1.1]heptane-2-carboxylate (1261243-55-3) → tert-butyl (1S,2S,3S,5R)-3-benzylamino-6,6-dimethylbicyclo[3.1.1]heptane-2-carboxylate (1261243-59-7)

Guidance literature:

With 10% palladium on activated carbon; hydrogen; acetic acid; at 20 ℃; for 2h; under 760.051 Torr;

DOI:10.1016/j.tetasy.2010.09.009

Reference yield: 81.0%

tert-butyl (1S,2S,3S,5R)-3-benzylamino-6,6-dimethylbicyclo[3.1.1]heptane-2-carboxylate (1261243-59-7) → (1S,2S,3S,5R)-3-benzylamino-6,6-dimethylbicyclo[3.1.1]heptane-2-carboxylic acid hydrochloride (1261243-65-5)

Guidance literature:

With hydrogenchloride; In diethyl ether; water; at 20 ℃; for 24h;

DOI:10.1016/j.tetasy.2010.09.009

upstream raw materials:

tert-butyl (1S,2S,3S,5R)-3-(dibenzylamino)-6,6-dimethylbicyclo[3.1.1]heptane-2-carboxylate

Downstream raw materials:

(1S,2S,3S,5R)-3-benzylamino-6,6-dimethylbicyclo[3.1.1]heptane-2-carboxylic acid hydrochloride