Morpholin-4-yl-phosphonic acid (2R,3R,4R,5R)-4-[(2-chloro-phenoxy)-hydroxy-phosphoryloxy]-3-methoxy-5-[6-(4-methoxy-benzoylamino)-purin-9-yl]-tetrahydro-furan-2-ylmethyl ester 2,2,2-tribromo-ethyl ester

Base Information

Chemical Name:Morpholin-4-yl-phosphonic acid (2R,3R,4R,5R)-4-[(2-chloro-phenoxy)-hydroxy-phosphoryloxy]-3-methoxy-5-[6-(4-methoxy-benzoylamino)-purin-9-yl]-tetrahydro-furan-2-ylmethyl ester 2,2,2-tribromo-ethyl ester
CAS No.:77000-49-8
Molecular Formula:C₃₁H₃₄Br₃ClN₆O₁₂P₂
Molecular Weight:1019.76
Hs Code.:

Morpholin-4-yl-phosphonic acid (2R,3R,4R,5R)-4-[(2-chloro-phenoxy)-hydroxy-phosphoryloxy]-3-methoxy-5-[6-(4-methoxy-benzoylamino)-purin-9-yl]-tetrahydro-furan-2-ylmethyl ester 2,2,2-tribromo-ethyl ester

Synonyms:Morpholin-4-yl-phosphonic acid (2R,3R,4R,5R)-4-[(2-chloro-phenoxy)-hydroxy-phosphoryloxy]-3-methoxy-5-[6-(4-methoxy-benzoylamino)-purin-9-yl]-tetrahydro-furan-2-ylmethyl ester 2,2,2-tribromo-ethyl ester

Suppliers and Price of Morpholin-4-yl-phosphonic acid (2R,3R,4R,5R)-4-[(2-chloro-phenoxy)-hydroxy-phosphoryloxy]-3-methoxy-5-[6-(4-methoxy-benzoylamino)-purin-9-yl]-tetrahydro-furan-2-ylmethyl ester 2,2,2-tribromo-ethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of Morpholin-4-yl-phosphonic acid (2R,3R,4R,5R)-4-[(2-chloro-phenoxy)-hydroxy-phosphoryloxy]-3-methoxy-5-[6-(4-methoxy-benzoylamino)-purin-9-yl]-tetrahydro-furan-2-ylmethyl ester 2,2,2-tribromo-ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of Morpholin-4-yl-phosphonic acid (2R,3R,4R,5R)-4-[(2-chloro-phenoxy)-hydroxy-phosphoryloxy]-3-methoxy-5-[6-(4-methoxy-benzoylamino)-purin-9-yl]-tetrahydro-furan-2-ylmethyl ester 2,2,2-tribromo-ethyl ester

There total 10 articles about Morpholin-4-yl-phosphonic acid (2R,3R,4R,5R)-4-[(2-chloro-phenoxy)-hydroxy-phosphoryloxy]-3-methoxy-5-[6-(4-methoxy-benzoylamino)-purin-9-yl]-tetrahydro-furan-2-ylmethyl ester 2,2,2-tribromo-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 57575-15-2
2,2,2-tribromoethyl moprpholinophosphorochloridate

: 77000-49-8
Morpholin-4-yl-phosphonic acid (2R,3R,4R,5R)-4-[(2-chloro-phenoxy)-hydroxy-phosphoryloxy]-3-methoxy-5-[6-(4-methoxy-benzoylamino)-purin-9-yl]-tetrahydro-furan-2-ylmethyl ester 2,2,2-tribromo-ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 1-methylimidazole / acetonitrile; dioxane / 6 h

2: hydrazine hydrate / pyridine; acetic acid / 0.07 h / Ambient temperature

3: pyridine / 0.25 h / 20 °C

With 1-methyl-1H-imidazole; hydrazine hydrate; In 1,4-dioxane; pyridine; acetic acid; acetonitrile;
DOI:10.1021/jo00324a010

Reference yield:

: 72560-72-6
3'-O-methyl-2',5'-diacetyladenosine

: 77000-49-8
Morpholin-4-yl-phosphonic acid (2R,3R,4R,5R)-4-[(2-chloro-phenoxy)-hydroxy-phosphoryloxy]-3-methoxy-5-[6-(4-methoxy-benzoylamino)-purin-9-yl]-tetrahydro-furan-2-ylmethyl ester 2,2,2-tribromo-ethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) pyridine, 2.) CH₃ONa / 1.) 20 deg C, 16 h, 2.) methanol, dioxane, 15 min

2: 88 percent / pyridine / 16 h / 20 °C

3: 1.) triethylamine, 4-(dimethylamino)pyridine, 2.) tetra-n-butylammonium fluoride (TBAF) / 1.) dioxane, 40 min, 2.) THF, 30 min

4: 1-methylimidazole / acetonitrile; dioxane / 6 h

5: hydrazine hydrate / pyridine; acetic acid / 0.07 h / Ambient temperature

6: pyridine / 0.25 h / 20 °C

With pyridine; 1-methyl-1H-imidazole; dmap; tetrabutyl ammonium fluoride; sodium methylate; hydrazine hydrate; triethylamine; In 1,4-dioxane; pyridine; acetic acid; acetonitrile;
DOI:10.1021/jo00324a010

Reference yield:

: 72351-35-0
3'-O-methyl-6-N-p-anisoyladenosine

: 77000-49-8
Morpholin-4-yl-phosphonic acid (2R,3R,4R,5R)-4-[(2-chloro-phenoxy)-hydroxy-phosphoryloxy]-3-methoxy-5-[6-(4-methoxy-benzoylamino)-purin-9-yl]-tetrahydro-furan-2-ylmethyl ester 2,2,2-tribromo-ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 88 percent / pyridine / 16 h / 20 °C

2: 1.) triethylamine, 4-(dimethylamino)pyridine, 2.) tetra-n-butylammonium fluoride (TBAF) / 1.) dioxane, 40 min, 2.) THF, 30 min

3: 1-methylimidazole / acetonitrile; dioxane / 6 h

4: hydrazine hydrate / pyridine; acetic acid / 0.07 h / Ambient temperature

5: pyridine / 0.25 h / 20 °C

With pyridine; 1-methyl-1H-imidazole; dmap; tetrabutyl ammonium fluoride; hydrazine hydrate; triethylamine; In 1,4-dioxane; pyridine; acetic acid; acetonitrile;
DOI:10.1021/jo00324a010