(4S)-4-tert-butyl-2-[4'-(2'',3'',5'',6''-tetrafluorobenzyloxymethyl)-2'-(di-ortho-tolylphosphanyl)-phenyl]-4,5-dihydrooxazole

Base Information

Chemical Name:(4S)-4-tert-butyl-2-[4'-(2'',3'',5'',6''-tetrafluorobenzyloxymethyl)-2'-(di-ortho-tolylphosphanyl)-phenyl]-4,5-dihydrooxazole
CAS No.:1301708-30-4
Molecular Formula:C₃₅H₃₄F₄NO₂P
Molecular Weight:607.628
Hs Code.:

Synonyms:(4S)-4-tert-butyl-2-[4'-(2'',3'',5'',6''-tetrafluorobenzyloxymethyl)-2'-(di-ortho-tolylphosphanyl)-phenyl]-4,5-dihydrooxazole

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Chemical Property of (4S)-4-tert-butyl-2-[4'-(2'',3'',5'',6''-tetrafluorobenzyloxymethyl)-2'-(di-ortho-tolylphosphanyl)-phenyl]-4,5-dihydrooxazole

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Technology Process of (4S)-4-tert-butyl-2-[4'-(2'',3'',5'',6''-tetrafluorobenzyloxymethyl)-2'-(di-ortho-tolylphosphanyl)-phenyl]-4,5-dihydrooxazole

There total 6 articles about (4S)-4-tert-butyl-2-[4'-(2'',3'',5'',6''-tetrafluorobenzyloxymethyl)-2'-(di-ortho-tolylphosphanyl)-phenyl]-4,5-dihydrooxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1301708-18-8
(4S)-4-tert-butyl-2-[4'-hydroxymethyl-2'-(di-ortho-tolylphosphanyl)-phenyl]-4,5-dihydrooxazole

: 53001-73-3
3-(bromomethyl)-1,2,4,5-tetrafluorobenzene

: 1301708-30-4
(4S)-4-tert-butyl-2-[4'-(2'',3'',5'',6''-tetrafluorobenzyloxymethyl)-2'-(di-ortho-tolylphosphanyl)-phenyl]-4,5-dihydrooxazole

Guidance literature:: (4S)-4-tert-butyl-2-[4'-hydroxymethyl-2'-(di-ortho-tolylphosphanyl)-phenyl]-4,5-dihydrooxazole; With potassium hydride; In tetrahydrofuran; at 0 - 20 ℃; for 2h; Inert atmosphere;

3-(bromomethyl)-1,2,4,5-tetrafluorobenzene; In tetrahydrofuran; at 20 ℃; for 19h; Inert atmosphere;
DOI:10.1002/chem.201003314

Reference yield:

: 874-89-5
4-Cyanobenzyl alcohol

: 1301708-30-4
(4S)-4-tert-butyl-2-[4'-(2'',3'',5'',6''-tetrafluorobenzyloxymethyl)-2'-(di-ortho-tolylphosphanyl)-phenyl]-4,5-dihydrooxazole

Guidance literature:: Multi-step reaction with 5 steps

1.1: 1H-imidazole / dichloromethane / 23.25 h / 0 - 20 °C / Inert atmosphere

2.1: zinc(II) chloride / chlorobenzene / 71 h / Inert atmosphere; Reflux

3.1: N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium / cyclohexane; pentane / 1.92 h / -78 - 0 °C / Inert atmosphere

3.2: 15 h / 0 - 20 °C / Inert atmosphere

4.1: tetra-n-butylammoniumfluoride trihydrate / tetrahydrofuran / 3.5 h / 20 °C / Inert atmosphere

5.1: potassium hydride / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere

5.2: 19 h / 20 °C / Inert atmosphere

With 1H-imidazole; N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium; potassium hydride; tetra-n-butylammoniumfluoride trihydrate; zinc(II) chloride; In tetrahydrofuran; dichloromethane; cyclohexane; chlorobenzene; pentane;
DOI:10.1002/chem.201003314

Reference yield:

: 1301708-11-1
(4S)-4-tert-butyl-2-[4-(tert-butyldimethylsilanyloxymethyl)-phenyl]-4,5-dihydrooxazole

: 1301708-30-4
(4S)-4-tert-butyl-2-[4'-(2'',3'',5'',6''-tetrafluorobenzyloxymethyl)-2'-(di-ortho-tolylphosphanyl)-phenyl]-4,5-dihydrooxazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium / cyclohexane; pentane / 1.92 h / -78 - 0 °C / Inert atmosphere

1.2: 15 h / 0 - 20 °C / Inert atmosphere

2.1: tetra-n-butylammoniumfluoride trihydrate / tetrahydrofuran / 3.5 h / 20 °C / Inert atmosphere

3.1: potassium hydride / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere

3.2: 19 h / 20 °C / Inert atmosphere

With N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium; potassium hydride; tetra-n-butylammoniumfluoride trihydrate; In tetrahydrofuran; cyclohexane; pentane;
DOI:10.1002/chem.201003314