53001-73-3

Usage

Chemical Properties

clear colorless to yellowish or

InChI:InChI=1/C7H3BrF4/c8-2-3-6(11)4(9)1-5(10)7(3)12/h1H,2H2

Upstream product

• 4084-38-2 (2,3,5,6-tetrafluorophenyl)methanol 
• 1559-88-2 1-bromo-2,3,5,6-tetrafluorobenzene 
• 5230-78-4 2,3,5,6-tetrafluorotoluene 
• 652-18-6 2,3,5,6-tetrafluorobenzoic acid 

Downstream Products

• 873463-86-6 thioacetic acid S-(2,3,5,6-tetrafluorobenzyl) ester 
• 1093786-43-6 C₂₀H₂₆F₄N₂O₃ 
• 1186653-94-0 2,4-dimethyl-6-[(2,3,5,6-tetrafluorophenyl)methyl]-4H-thieno[3,2-b]pyrrole[3,2-d]pyridazinone 
• 1301708-26-8 (3aR,7aR)-1-(2',3',5',6'-tetrafluorobenzyl)-2-(2''-(diphenylphosphanyl)phenyl)-3a,4,5,6,7,7a-hexahydro-1H-benzimidazole 
• 1301708-30-4 (4S)-4-tert-butyl-2-[4'-(2'',3'',5'',6''-tetrafluorobenzyloxymethyl)-2'-(di-ortho-tolylphosphanyl)-phenyl]-4,5-dihydrooxazole 
• 1301708-37-1 (4S)-4-[1'-(2'',3'',5'',6''-tetrafluorobenzyloxy)-1'-methyl-ethyl]-2-(2'''-diphenylphosphanylphenyl)-4,5-dihydrooxazole 
• 1361055-51-7 C₅₆H₂₈F₁₆I₄O₄ 
• 1360880-90-5 1-(chloromethyl)-2,3,5,6-tetrafluoro-4-iodobenzene 
• 107267-44-7 3-Chloromethyl-1,2,4,5-tetrafluoro-benzene 
• 1455006-38-8 benzyl 2-(benzyloxy)-4-(N-(4-cyclohexylbenzyl)-2-(2,3,4,5,6-pentafluoro-N-(2,3,5,6,-tetrafluorobenzyl)phenylsulfonamido)acetamido)benzoate 
• 53001-67-5 (2,3,5,6-tetrafluorophenyl)acetonitrile 

Relevant academic research and scientific papers

Direct evidence of edge-to-face CH/π interaction for PAR-1 thrombin receptor activation

Heptapeptide SFLLRNP is a receptor–tethered ligand of protease-activated receptor 1 (PAR-1), and its Phe at position 2 is essential for the aggregation of human platelets. To validate the structural elements of the Phe-phenyl group in receptor activation, we have synthesized a complete set of S/Phe/LLRNP peptides comprising different series of fluorophenylalanine isomers (Fn)Phe, where n = 1, 2, 3, and 5. Phe-2-phenyl was strongly suggested to be involved in the edge-to-face CH/π interaction with the receptor aromatic group. In the present study, to prove this receptor interaction definitively, we synthesized another series of peptide analogs containing (F4)Phe-isomers, with the phenyl group of each isomer possessing only one hydrogen atom at the ortho, meta, or para position. When the peptides were assayed for their platelet aggregation activity, S/(2,3,4,6-F4)Phe/LLRNP and S/(2,3,4,5-F4)Phe/LLRNP exhibited noticeable activity (34% and 6% intensities of the native peptide, respectively), whereas S/(2,3,5,6-F4)Phe/LLRNP was completely inactive. The results indicated that, at the ortho and meta positions but not at the para position, benzene-hydrogen atoms are required for the CH/π interaction to activate the receptor. The results provided a decisive evidence of the molecular recognition property of Phe, the phenyl benzene-hydrogen atom of which participates directly in the interaction with the receptor aromatic π plane.

Halogenated esters

Compounds of formula I wherein R1 and R2 are haloalkyl or halo, X is O, S, S(O), SO2 or NR4 where R4 is H or alkyl, R3 is alkyl and n is 1 to 4, and compositions comprising them, useful as insecticides. STR1