5-cyclopropyl-3-(trifluoromethyl)-1,2-benzenediamine

Base Information

• Chemical Name: 5-cyclopropyl-3-(trifluoromethyl)-1,2-benzenediamine
• CAS No.: 1326310-55-7
• Molecular Formula: C₁₀H₁₁F₃N₂
• Molecular Weight: 216.206
• Mol file: 1326310-55-7.mol

Synonyms:5-cyclopropyl-3-(trifluoromethyl)-1,2-benzenediamine

Chemical Property of 5-cyclopropyl-3-(trifluoromethyl)-1,2-benzenediamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-cyclopropyl-3-(trifluoromethyl)-1,2-benzenediamine

There total 5 articles about 5-cyclopropyl-3-(trifluoromethyl)-1,2-benzenediamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

4-cyclopropyl-2-nitro-6-(trifluoromethyl)aniline (1326310-54-6) → 5-cyclopropyl-3-(trifluoromethyl)-1,2-benzenediamine (1326310-55-7)

Guidance literature:

With formic acid; triethylamine; palladium 10% on activated carbon; In tetrahydrofuran; at 65 ℃; for 16h;

Reference yield:

4-bromo-2-trifluoromethyl-aniline (445-02-3) → 5-cyclopropyl-3-(trifluoromethyl)-1,2-benzenediamine (1326310-55-7)

Guidance literature:

Multi-step reaction with 4 steps

1.1: chloroform / 0 - 20 °C

2.1: nitric acid / sulfuric acid / 5 - 12 °C

2.2: 100 °C

3.1: potassium phosphate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 4 h / 100 °C

4.1: triethylamine; formic acid / palladium 10% on activated carbon / tetrahydrofuran / 16 h / 65 °C

With potassium phosphate; formic acid; nitric acid; triethylamine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sulfuric acid; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; chloroform;

Reference yield:

N-(4-bromo-2-trifluoromethyl-phenyl)-acetamide (29124-62-7) → 5-cyclopropyl-3-(trifluoromethyl)-1,2-benzenediamine (1326310-55-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: nitric acid / sulfuric acid / 5 - 12 °C

1.2: 100 °C

2.1: potassium phosphate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 4 h / 100 °C

3.1: triethylamine; formic acid / palladium 10% on activated carbon / tetrahydrofuran / 16 h / 65 °C

With potassium phosphate; formic acid; nitric acid; triethylamine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sulfuric acid; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane;

upstream raw materials:

4-bromo-2-nitro-6-trilfuoromethyl-phenylamine

N-(4-bromo-2-nitro-6-trifluoromethyl-phenyl)-acetamide

N-(4-bromo-2-trifluoromethyl-phenyl)-acetamide

4-bromo-2-trifluoromethyl-aniline