29124-62-7

Basic information

• Product Name: N-(4-bromo-2-trifluoromethl-pheny)-Acetamide
• Synonyms: N-(4-bromo-2-trifluoromethl-pheny)-Acetamide;Acetamide,N-[4-bromo-2-(trifluoromethyl)phenyl]-
• CAS NO: 29124-62-7
• Molecular Formula: C₉H₇BrF₃NO
• Molecular Weight: 282.058
• Mol File: 29124-62-7.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-(4-bromo-2-trifluoromethl-pheny)-Acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-bromo-2-trifluoromethl-pheny)-Acetamide(29124-62-7)
• EPA Substance Registry System: N-(4-bromo-2-trifluoromethl-pheny)-Acetamide(29124-62-7)

Safety Data

• Hazardous Substances Data: 29124-62-7(Hazardous Substances Data)

Usage

General Description

N-(4-bromo-2-trifluoromethl-pheny)-Acetamide is a chemical compound with the molecular formula C10H8BrF3NO. N-(4-bromo-2-trifluoromethl-pheny)-Acetamide is found to have applications in pharmaceutical and organic synthesis. It is commonly used as an intermediate in the production of various pharmaceutical drugs, particularly those used for treating pain and inflammation. Its chemical structure contains a bromine atom, two trifluoromethyl groups, and an acetamide functional group. Overall, N-(4-bromo-2-trifluoromethl-pheny)-Acetamide is a versatile compound with important applications in the pharmaceutical industry.

Upstream product

• 344-62-7 N-[2-(trifluoromethyl)phenyl]acetamide 
• 103-88-8 4-bromoacetanilide 
• 2926-29-6 Langlois reagent 
• 445-02-3 4-bromo-2-trifluoromethyl-aniline 
• 75-36-5 acetyl chloride 

Downstream Products

• 400610-45-9 1-(4-bromo-2-trifluoromethyl-phenyl)-5-methyl-1H-tetrazole 
• 1326310-55-7 5-cyclopropyl-3-(trifluoromethyl)-1,2-benzenediamine 
• 1326310-54-6 4-cyclopropyl-2-nitro-6-(trifluoromethyl)aniline 
• 672961-18-1 N-[4-(4'-pyridyl)-2-trifluoromethylphenyl]acetamide 
• 179062-00-1 N-(4-bromo-2-nitro-6-trifluoromethyl-phenyl)-acetamide 
• 157026-18-1 4-bromo-2-nitro-6-trilfuoromethyl-phenylamine 
• 157026-19-2 5-bromo-3-(trifluoromethyl)-1,2-benzenediamine 

Relevant articles and documents

Triptycenyl Sulfide: A Practical and Active Catalyst for Electrophilic Aromatic Halogenation Using N-Halosuccinimides

A Lewis base catalyst Trip-SMe (Trip = triptycenyl) for electrophilic aromatic halogenation using N-halosuccinimides (NXS) is introduced. In the presence of an appropriate activator (as a noncoordinating-anion source), a series of unactivated aromatic compounds were halogenated at ambient temperature using NXS. This catalytic system was applicable to transformations that are currently unachievable except for the use of Br2 or Cl2: e.g., multihalogenation of naphthalene, regioselective bromination of BINOL, etc. Controlled experiments revealed that the triptycenyl substituent exerts a crucial role for the catalytic activity, and kinetic experiments implied the occurrence of a sulfonium salt [Trip-S(Me)Br][SbF6] as an active species. Compared to simple dialkyl sulfides, Trip-SMe exhibited a significant charge-separated ion pair character within the halonium complex whose structural information was obtained by the single-crystal X-ray analysis. A preliminary computational study disclosed that the πsystem of the triptycenyl functionality is a key motif to consolidate the enhancement of electrophilicity.

Preparation 2-trifluoromethyl-4-substituted aniline compounds

The invention relates to a method for preparing 2-trifluoromethyl-4-substituted phenylamine and 2-trifluoromethyl-4-substituted acetanilide. The method for preparing the2-trifluoromethyl-4-substituted phenylamine and 2-trifluoromethyl-4-substituted acetanilide comprises the following main step: in the presence of sodium trifluoromethanesulfonate and tert-butyl hydroperoxide but no metal salt catalyst and under the stirring condition, maintaining a 4-substituted phenylamine compound (concrete structure shown in a formula II is described in the specification) in a reaction medium of mixture composed of dichloromethane and water at the temperature of 0-25 DEG C for 72-120 hours, so that the 2-trifluoromethyl-4-substituted phenylamine target product is obtained. The preparation method provided by the invention has potential commercial value.

Palladium-catalyzed trifluoromethylation of aromatic C-H bond directed by an acetamino group

The first palladium-catalyzed ortho-trifluoromethylation of the aromatic C-H bond directed by an acetamino group is reported. This method provides an efficient and green approach to synthesize the highly biological potential key structure of ortho-CF3 acetanilides and anilines.