1-(2-((t-butyldimethylsilyl)oxy)ethyl)-4-(3-methoxy-[1,1′-biphenyl]-4-yl)piperazine

Base Information

Chemical Name:1-(2-((t-butyldimethylsilyl)oxy)ethyl)-4-(3-methoxy-[1,1′-biphenyl]-4-yl)piperazine
CAS No.:1563175-03-0
Molecular Formula:C₂₅H₃₈N₂O₂Si
Molecular Weight:426.674
Hs Code.:

Synonyms:1-(2-((t-butyldimethylsilyl)oxy)ethyl)-4-(3-methoxy-[1,1′-biphenyl]-4-yl)piperazine

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Chemical Property of 1-(2-((t-butyldimethylsilyl)oxy)ethyl)-4-(3-methoxy-[1,1′-biphenyl]-4-yl)piperazine

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Technology Process of 1-(2-((t-butyldimethylsilyl)oxy)ethyl)-4-(3-methoxy-[1,1′-biphenyl]-4-yl)piperazine

There total 5 articles about 1-(2-((t-butyldimethylsilyl)oxy)ethyl)-4-(3-methoxy-[1,1′-biphenyl]-4-yl)piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: (2-bromo-ethyl)-tert-butyldimethylsilane

: 506442-30-4
1-(3-methoxy-[1,1′-biphenyl]-4-yl)piperazine

: 1563175-03-0
1-(2-((t-butyldimethylsilyl)oxy)ethyl)-4-(3-methoxy-[1,1′-biphenyl]-4-yl)piperazine

Guidance literature:: With potassium carbonate; In acetonitrile; for 12h; Inert atmosphere; Reflux;
DOI:10.1021/jm401883v

Reference yield:

: 35386-24-4
1-(2-Methoxyphenyl)piperazine

: 1563175-03-0
1-(2-((t-butyldimethylsilyl)oxy)ethyl)-4-(3-methoxy-[1,1′-biphenyl]-4-yl)piperazine

Guidance literature:: Multi-step reaction with 5 steps

1.1: bromine / dichloromethane / 2 h / 0 °C / Inert atmosphere

1.2: Inert atmosphere

2.1: triethylamine / dichloromethane / 12 h / 20 °C / Inert atmosphere

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / water; ethanol; 1,2-dimethoxyethane / 2 h / 95 °C / Inert atmosphere

4.1: trifluoroacetic acid / dichloromethane / 4 h / 20 °C / Inert atmosphere

5.1: potassium carbonate / acetonitrile / 12 h / Inert atmosphere; Reflux

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; bromine; sodium carbonate; potassium carbonate; triethylamine; trifluoroacetic acid; In 1,2-dimethoxyethane; ethanol; dichloromethane; water; acetonitrile; 3.1: |Suzuki Coupling;
DOI:10.1021/jm401883v

Reference yield:

: 1563175-02-9
t-butyl 4-(3-Methoxybiphenyl-4-yl)piperazine-1-carboxylate

: 1563175-03-0
1-(2-((t-butyldimethylsilyl)oxy)ethyl)-4-(3-methoxy-[1,1′-biphenyl]-4-yl)piperazine

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane / 4 h / 20 °C / Inert atmosphere

2: potassium carbonate / acetonitrile / 12 h / Inert atmosphere; Reflux

With potassium carbonate; trifluoroacetic acid; In dichloromethane; acetonitrile;
DOI:10.1021/jm401883v