4-(4-(2-((2-amino-4,5,6,7-tetrahydrobenzo[d]thiazol-6-yl)(propyl)amino)ethyl)piperazin-1-yl)[1,1′-biphenyl]-3-ol

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Chemical Name:4-(4-(2-((2-amino-4,5,6,7-tetrahydrobenzo[d]thiazol-6-yl)(propyl)amino)ethyl)piperazin-1-yl)[1,1′-biphenyl]-3-ol
CAS No.:1563175-07-4
Molecular Formula:C₂₈H₃₇N₅OS
Molecular Weight:491.701
Hs Code.:

Synonyms:

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Chemical Property of 4-(4-(2-((2-amino-4,5,6,7-tetrahydrobenzo[d]thiazol-6-yl)(propyl)amino)ethyl)piperazin-1-yl)[1,1′-biphenyl]-3-ol

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Technology Process of 4-(4-(2-((2-amino-4,5,6,7-tetrahydrobenzo[d]thiazol-6-yl)(propyl)amino)ethyl)piperazin-1-yl)[1,1′-biphenyl]-3-ol

There total 9 articles about 4-(4-(2-((2-amino-4,5,6,7-tetrahydrobenzo[d]thiazol-6-yl)(propyl)amino)ethyl)piperazin-1-yl)[1,1′-biphenyl]-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1563175-06-3
N₆-(2-(4-(3-methoxybiphenyl-4-yl)piperazin-1-yl)ethyl)-N₆-propyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine

: 1563175-07-4
4-(4-(2-((2-amino-4,5,6,7-tetrahydrobenzo[d]thiazol-6-yl)(propyl)amino)ethyl)piperazin-1-yl)[1,1′-biphenyl]-3-ol

Guidance literature:: With hydrogen bromide; In water; Inert atmosphere; Reflux;
DOI:10.1021/jm401883v

Reference yield:

: 35386-24-4
1-(2-Methoxyphenyl)piperazine

: 1563175-07-4
4-(4-(2-((2-amino-4,5,6,7-tetrahydrobenzo[d]thiazol-6-yl)(propyl)amino)ethyl)piperazin-1-yl)[1,1′-biphenyl]-3-ol

Guidance literature:: Multi-step reaction with 9 steps

1.1: bromine / dichloromethane / 2 h / 0 °C / Inert atmosphere

1.2: Inert atmosphere

2.1: triethylamine / dichloromethane / 12 h / 20 °C / Inert atmosphere

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / water; ethanol; 1,2-dimethoxyethane / 2 h / 95 °C / Inert atmosphere

4.1: trifluoroacetic acid / dichloromethane / 4 h / 20 °C / Inert atmosphere

5.1: potassium carbonate / acetonitrile / 12 h / Inert atmosphere; Reflux

6.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

7.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.25 h / -78 °C / Inert atmosphere

7.2: 1.33 h / 20 °C / Inert atmosphere

8.1: sodium tris(acetoxy)borohydride / dichloromethane / 48 h / 20 °C / Inert atmosphere

9.1: hydrogen bromide / water / Inert atmosphere; Reflux

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; oxalyl dichloride; tetrabutyl ammonium fluoride; hydrogen bromide; bromine; sodium tris(acetoxy)borohydride; sodium carbonate; potassium carbonate; dimethyl sulfoxide; triethylamine; trifluoroacetic acid; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; dichloromethane; water; acetonitrile; 3.1: |Suzuki Coupling / 7.1: |Swern Oxidation / 7.2: |Swern Oxidation;
DOI:10.1021/jm401883v

Reference yield:

: 1563175-03-0
1-(2-((t-butyldimethylsilyl)oxy)ethyl)-4-(3-methoxy-[1,1′-biphenyl]-4-yl)piperazine

: 1563175-07-4
4-(4-(2-((2-amino-4,5,6,7-tetrahydrobenzo[d]thiazol-6-yl)(propyl)amino)ethyl)piperazin-1-yl)[1,1′-biphenyl]-3-ol

Guidance literature:: Multi-step reaction with 4 steps

1.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

2.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.25 h / -78 °C / Inert atmosphere

2.2: 1.33 h / 20 °C / Inert atmosphere

3.1: sodium tris(acetoxy)borohydride / dichloromethane / 48 h / 20 °C / Inert atmosphere

4.1: hydrogen bromide / water / Inert atmosphere; Reflux

With oxalyl dichloride; tetrabutyl ammonium fluoride; hydrogen bromide; sodium tris(acetoxy)borohydride; dimethyl sulfoxide; In tetrahydrofuran; dichloromethane; water; 2.1: |Swern Oxidation / 2.2: |Swern Oxidation;
DOI:10.1021/jm401883v