3-(tert-butyloxycarbonylamino)-4-hydroxy-1-(4-methoxyphenyl)butan-1-one

Base Information

• Chemical Name: 3-(tert-butyloxycarbonylamino)-4-hydroxy-1-(4-methoxyphenyl)butan-1-one
• CAS No.: 1434254-02-0
• Molecular Formula: C₁₆H₂₃NO₅
• Molecular Weight: 309.362
• Mol file: 1434254-02-0.mol

Synonyms:3-(tert-butyloxycarbonylamino)-4-hydroxy-1-(4-methoxyphenyl)butan-1-one

Chemical Property of 3-(tert-butyloxycarbonylamino)-4-hydroxy-1-(4-methoxyphenyl)butan-1-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(tert-butyloxycarbonylamino)-4-hydroxy-1-(4-methoxyphenyl)butan-1-one

There total 8 articles about 3-(tert-butyloxycarbonylamino)-4-hydroxy-1-(4-methoxyphenyl)butan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

2-(tert-butyloxycarbonylamino)-3-[2-(4-methoxyphenyl)-1,3-dithian-2-yl]propan-1-ol (1434253-94-7) → 3-(tert-butyloxycarbonylamino)-4-hydroxy-1-(4-methoxyphenyl)butan-1-one (1434254-02-0)

Guidance literature:

With water; iodine; sodium hydrogencarbonate; In acetonitrile;

DOI:10.1016/j.tetasy.2015.04.016

Reference yield:

2-(tert-butyloxycarbonylamino)-3-[2-(4-methoxyphenyl)-1,3-dithian-2-yl]propan-1-ol (1434253-94-7) → 3-(tert-butyloxycarbonylamino)-4-hydroxy-1-(4-methoxyphenyl)butan-1-one (1434254-02-0) + C16H23NO5

Guidance literature:

With iodine; sodium hydrogencarbonate; In acetonitrile; at 0 - 30 ℃; for 1h; Overall yield = 89 %; Overall yield = 550 mg;

DOI:10.1002/ejoc.201201128

Reference yield:

2-(4-methoxyphenyl)-1,3-dithiane (24588-72-5) → 3-(tert-butyloxycarbonylamino)-4-hydroxy-1-(4-methoxyphenyl)butan-1-one (1434254-02-0) + C16H23NO5

Guidance literature:

Multi-step reaction with 3 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.67 h / -20 °C

1.2: -20 °C

2.1: trifluoroacetic acid / methanol / 0 °C

3.1: sodium hydrogencarbonate; iodine / acetonitrile / 1 h / 0 - 30 °C

With n-butyllithium; iodine; sodium hydrogencarbonate; trifluoroacetic acid; In tetrahydrofuran; methanol; hexane; acetonitrile;

DOI:10.1002/ejoc.201201128

upstream raw materials:

2-(tert-butyloxycarbonylamino)-3-[2-(4-methoxyphenyl)-1,3-dithian-2-yl]propan-1-ol

C₂₂H₃₃NO₄S₂

C₁₁H₂₀INO₃

2-(4-methoxyphenyl)-1,3-dithiane

Downstream raw materials:

2-(tert-butyloxycarbonylamino)-4-(4-methoxyphenyl)-4-oxobutanoic acid