(L)-4-(2',6'-dimethoxyphenyl)-phenylalanine

Base Information

Chemical Name:(L)-4-(2',6'-dimethoxyphenyl)-phenylalanine
CAS No.:347382-77-8
Molecular Formula:C₁₇H₁₉NO₄
Molecular Weight:301.342
Hs Code.:

Synonyms:(L)-4-(2',6'-dimethoxyphenyl)-phenylalanine

Suppliers and Price of (L)-4-(2',6'-dimethoxyphenyl)-phenylalanine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Activate Scientific
4-(2,6-Dimethoxyphenyl)-L-phenylalanine 95% ee
1 g
$ 1064.00

Acrotein
4-(2,6-Dimethoxyphenyl)-L-phenylalanine 97%
0.5g
$ 586.67

Total 1 raw suppliers

Chemical Property of (L)-4-(2',6'-dimethoxyphenyl)-phenylalanine

Chemical Property:

Boiling Point:433.4±45.0 °C(Predicted)
Density:1.201±0.06 g/cm3(Predicted)

Purity/Quality:

95%-98% ^*data from raw suppliers

4-(2,6-Dimethoxyphenyl)-L-phenylalanine 95% ee ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (L)-4-(2',6'-dimethoxyphenyl)-phenylalanine

There total 6 articles about (L)-4-(2',6'-dimethoxyphenyl)-phenylalanine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2-tert-butoxycarbonylamino-3-(2',6'-dimethoxy-biphenyl-4-yl)-propionic acid

: 347382-77-8
(L)-4-(2',6'-dimethoxyphenyl)-phenylalanine

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 0.5h;
DOI:10.1016/j.bmc.2012.07.010

Reference yield:

: 60-18-4,18875-48-4,25619-78-7,30704-25-7
L-tyrosine

: 347382-77-8
(L)-4-(2',6'-dimethoxyphenyl)-phenylalanine

Guidance literature:: Multi-step reaction with 6 steps

1.1: thionyl chloride / 4 h / Reflux

2.1: triethylamine / methanol / 20 °C / Cooling with ice; Inert atmosphere

3.1: pyridine / dichloromethane / 0.5 h / -15 °C / Inert atmosphere

4.1: potassium phosphate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate / toluene; N,N-dimethyl-formamide / 90 °C / Inert atmosphere

5.1: sodium hydroxide / methanol; tetrahydrofuran / 20 °C

5.2: pH 3

6.1: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; pyridine; potassium phosphate; thionyl chloride; palladium diacetate; triethylamine; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; toluene; 4.1: |Suzuki Coupling;
DOI:10.1016/j.bmc.2012.07.010

Reference yield:

: 1080-06-4
L-Tyr-OMe

: 347382-77-8
(L)-4-(2',6'-dimethoxyphenyl)-phenylalanine

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / methanol / 20 °C / Cooling with ice; Inert atmosphere

2.1: pyridine / dichloromethane / 0.5 h / -15 °C / Inert atmosphere

3.1: potassium phosphate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate / toluene; N,N-dimethyl-formamide / 90 °C / Inert atmosphere

4.1: sodium hydroxide / methanol; tetrahydrofuran / 20 °C

4.2: pH 3

5.1: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; pyridine; potassium phosphate; palladium diacetate; triethylamine; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; toluene; 3.1: |Suzuki Coupling;
DOI:10.1016/j.bmc.2012.07.010