3-Chloro-4-fluorophenetole

Base Information

Chemical Name:3-Chloro-4-fluorophenetole
CAS No.:289039-45-8
Molecular Formula:C8H8ClFO
Molecular Weight:174.5999
Hs Code.:2909309090
DSSTox Substance ID:DTXSID80378653
Wikidata:Q82168161
Mol file:289039-45-8.mol

Synonyms:3-Chloro-4-fluorophenetole;2-chloro-4-ethoxy-1-fluorobenzene;289039-45-8;Benzene, 2-chloro-4-ethoxy-1-fluoro-;SCHEMBL1359316;DTXSID80378653;FBCRDQDDPKYKBM-UHFFFAOYSA-N;MFCD00672984;AKOS006230561;2-chloranyl-4-ethoxy-1-fluoranyl-benzene;CS-0190540;FT-0659421;E89502;A819669

Suppliers and Price of 3-Chloro-4-fluorophenetole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
2-Chloro-4-ethoxy-1-fluorobenzene 97%
5g
$ 395.00

American Custom Chemicals Corporation
3-CHLORO-4-FLUOROPHENETOLE 95.00%
10G
$ 1334.03

American Custom Chemicals Corporation
3-CHLORO-4-FLUOROPHENETOLE 95.00%
5G
$ 909.56

Total 13 raw suppliers

Chemical Property of 3-Chloro-4-fluorophenetole

Chemical Property:

Vapor Pressure:0.157mmHg at 25°C
Refractive Index:1.492
Boiling Point:221.7 °C at 760 mmHg
Flash Point:87.9 °C
PSA：9.23000
Density:1.195 g/cm³
LogP:2.87780
XLogP3:3.1
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:174.0247707
Heavy Atom Count:11
Complexity:121

Purity/Quality:

97% ^*data from raw suppliers

2-Chloro-4-ethoxy-1-fluorobenzene 97% ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xi
Hazard Codes:Xi
Statements: 36/37/38
Safety Statements: 26-36

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC1=CC(=C(C=C1)F)Cl

Technology Process of 3-Chloro-4-fluorophenetole

There total 1 articles about 3-Chloro-4-fluorophenetole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 64-67-5
diethyl sulfate

: 2613-23-2
3-chloro-4-fluorophenol

: 289039-45-8
2-Chloro-4-ethoxy-1-fluorobenzene

Guidance literature:: With potassium carbonate; In acetone; for 3h; Reflux;

Reference yield:

: 289039-45-8
2-Chloro-4-ethoxy-1-fluorobenzene

: 68-12-2,33513-42-7
N,N-dimethyl-formamide

: 1350322-54-1
2-Chloro-6-ethoxy-3-fluorobenzaldehyde

Guidance literature:: 2-Chloro-4-ethoxy-1-fluorobenzene; With lithium diisopropyl amide; In tetrahydrofuran; n-heptane; ethylbenzene; at -78 ℃; for 0.116667h;

N,N-dimethyl-formamide; In tetrahydrofuran; n-heptane; ethylbenzene; at -60 ℃; for 0.666667h;

With water; ammonium chloride; In tetrahydrofuran; n-heptane; ethylbenzene;

Reference yield:

: 289039-45-8
2-Chloro-4-ethoxy-1-fluorobenzene

: 1350322-50-7
5-Bromo-3-[1-(2-chloro-6-ethoxy-3-fluorophenyl)ethyl]-1H-pyrrolo[2,3-b]pyridine

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium diisopropyl amide / n-heptane; tetrahydrofuran; ethylbenzene / 0.12 h / -78 °C

1.2: 0.67 h / -60 °C

2.1: potassium hydroxide / methanol / 48 h / 20 °C

3.1: boron trifluoride diethyl etherate / tetrahydrofuran / 1 h / -78 °C

3.2: 12 h / 50 °C

With boron trifluoride diethyl etherate; potassium hydroxide; lithium diisopropyl amide; In tetrahydrofuran; methanol; n-heptane; ethylbenzene;