5-(3-dimethylamino-1-propoxy)-3-(4-trifluoromethylphenyl)pyrazolo[1,5-a]quinazoline hydrochloride

Base Information

Chemical Name:5-(3-dimethylamino-1-propoxy)-3-(4-trifluoromethylphenyl)pyrazolo[1,5-a]quinazoline hydrochloride
CAS No.:1456789-37-9
Molecular Formula:C₂₂H₂₁F₃N₄O*ClH
Molecular Weight:450.891
Hs Code.:

Synonyms:5-(3-dimethylamino-1-propoxy)-3-(4-trifluoromethylphenyl)pyrazolo[1,5-a]quinazoline hydrochloride

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-(3-dimethylamino-1-propoxy)-3-(4-trifluoromethylphenyl)pyrazolo[1,5-a]quinazoline hydrochloride

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Technology Process of 5-(3-dimethylamino-1-propoxy)-3-(4-trifluoromethylphenyl)pyrazolo[1,5-a]quinazoline hydrochloride

There total 2 articles about 5-(3-dimethylamino-1-propoxy)-3-(4-trifluoromethylphenyl)pyrazolo[1,5-a]quinazoline hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 3179-63-3
3-Dimethylamino-1-propanol

: 1456789-14-2
3-(4-trifluoromethylphenyl)pyrazolo[1,5-a]quinazolin-5(4H)-one

: 1456789-37-9
5-(3-dimethylamino-1-propoxy)-3-(4-trifluoromethylphenyl)pyrazolo[1,5-a]quinazoline hydrochloride

Guidance literature:: 3-(4-trifluoromethylphenyl)pyrazolo[1,5-a]quinazolin-5(4H)-one; With triphenylphosphine; In tetrahydrofuran; at 20 ℃; for 0.0833333h; Inert atmosphere;

With diethylazodicarboxylate; In tetrahydrofuran; at 20 ℃; for 0.25h; Inert atmosphere;

3-Dimethylamino-1-propanol; Further stages;
DOI:10.1021/jm400932c

Reference yield:

: 2338-75-2
4-(Trifluoromethyl)phenylacetonitrile

: 1456789-37-9
5-(3-dimethylamino-1-propoxy)-3-(4-trifluoromethylphenyl)pyrazolo[1,5-a]quinazoline hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1.1: aluminum oxide / 0.12 h / 150 °C / Microwave irradiation

2.1: triphenylphosphine / tetrahydrofuran / 0.08 h / 20 °C / Inert atmosphere

2.2: 0.25 h / 20 °C / Inert atmosphere

With aluminum oxide; triphenylphosphine; In tetrahydrofuran;
DOI:10.1021/jm400932c