2-FLUORO-4-METHOXYCINNAMIC ACID

Base Information

• Chemical Name: 2-FLUORO-4-METHOXYCINNAMIC ACID
• CAS No.: 696589-22-7
• Molecular Formula: C₁₀H₉FO₃
• Molecular Weight: 196.178
• Hs Code.: 2918999090
• Mol file: 696589-22-7.mol

Synonyms:(2E)-3-(2-fluoro-4-methoxyphenyl)prop-2-enoic acid;(2E)-3-(2-Fluoro-4-methoxyphenyl)acrylic acid;

Chemical Property of 2-FLUORO-4-METHOXYCINNAMIC ACID

Chemical Property:

• Vapor Pressure: 9.69E-05mmHg at 25°C
• Refractive Index: 1.571
• Boiling Point: 325 °C at 760 mmHg
• Flash Point: 150.3 °C
• PSA: 46.53000
• Density: 1.28 g/cm³
• LogP: 1.93210

Purity/Quality:

97% ^*data from raw suppliers

(E)-3-(2-Fluoro-4-methoxyphenyl)acrylicacid 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-FLUORO-4-METHOXYCINNAMIC ACID

There total 3 articles about 2-FLUORO-4-METHOXYCINNAMIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

malonic acid (141-82-2) + 2-fluoro-4-methoxy-benzaldehyde (331-64-6) → (E)-3-(2-fluoro-4-methoxyphenyl)acrylic acid (696589-22-7)

Guidance literature:

With piperidine; pyridine; at 90 ℃; Inert atmosphere;

DOI:10.1016/j.bmc.2017.08.047

Reference yield:

malonic acid (141-82-2) + 2-fluoro-4-methoxy-benzaldehyde (331-64-6) → 2-fluoro-4-methoxycinnamic acid (682805-00-1,696589-22-7)

Guidance literature:

With piperidine; pyridine; at 90 ℃;

DOI:10.1016/j.bmc.2020.115586

Reference yield:

→ (E)-3-(2-fluoro-4-methoxyphenyl)acrylic acid (696589-22-7)

Guidance literature:

With piperidine; pyridine; at 85 - 90 ℃; for 3h;

With hydrogenchloride; In water; at 0 ℃; for 0.75h;

upstream raw materials:

malonic acid

2-fluoro-4-methoxy-benzaldehyde

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