using 6-{4-[2-amino-1-(4-trifluoromethylphenyl)-ethyl]-piperazin-1-yl}-5-bromo-pyrimidin-4-ylamine

Base Information

Chemical Name:using 6-{4-[2-amino-1-(4-trifluoromethylphenyl)-ethyl]-piperazin-1-yl}-5-bromo-pyrimidin-4-ylamine
CAS No.:1427594-18-0
Molecular Formula:C₁₇H₂₀BrF₃N₆
Molecular Weight:445.285
Hs Code.:

Synonyms:using 6-{4-[2-amino-1-(4-trifluoromethylphenyl)-ethyl]-piperazin-1-yl}-5-bromo-pyrimidin-4-ylamine

Suppliers and Price of using 6-{4-[2-amino-1-(4-trifluoromethylphenyl)-ethyl]-piperazin-1-yl}-5-bromo-pyrimidin-4-ylamine

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Chemical Property of using 6-{4-[2-amino-1-(4-trifluoromethylphenyl)-ethyl]-piperazin-1-yl}-5-bromo-pyrimidin-4-ylamine

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Technology Process of using 6-{4-[2-amino-1-(4-trifluoromethylphenyl)-ethyl]-piperazin-1-yl}-5-bromo-pyrimidin-4-ylamine

There total 1 articles about using 6-{4-[2-amino-1-(4-trifluoromethylphenyl)-ethyl]-piperazin-1-yl}-5-bromo-pyrimidin-4-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 2-piperazin-1-yl-2-(4-trifluoromethylphenyl)ethylamine hydrochloride

: 663193-80-4
5-bromo-6-chloro-pyrimidin-4-ylamine

: 1427594-18-0
using 6-{4-[2-amino-1-(4-trifluoromethylphenyl)-ethyl]-piperazin-1-yl}-5-bromo-pyrimidin-4-ylamine

Guidance literature:: With potassium carbonate; In dimethyl sulfoxide; at 60 ℃; for 8h;

Reference yield: 75.0%

: 1427594-18-0
using 6-{4-[2-amino-1-(4-trifluoromethylphenyl)-ethyl]-piperazin-1-yl}-5-bromo-pyrimidin-4-ylamine

: 1765-93-1
4-fluoroboronic acid

: 1427594-20-4
6-{4-[2-Amino-1-(4-trifluoromethyl-phenyl)-ethyl]-piperazin-1-yl}-5-(4-fluoro-phenyl)-pyrimidin-4-ylamine

Guidance literature:: With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; caesium carbonate; In 1,4-dioxane; water; at 100 ℃; Sealed tube;

Reference yield:

: 1427594-18-0
using 6-{4-[2-amino-1-(4-trifluoromethylphenyl)-ethyl]-piperazin-1-yl}-5-bromo-pyrimidin-4-ylamine

: 1765-93-1
4-fluoroboronic acid

: 1427594-21-5
6-{4-[(S)-2-amino-1-(4-trifluoromethylphenyl)ethyl]piperazin-1-yl}-5-(4-fluorophenyl)pyrimidin-4-ylamine

: 1427594-22-6
6-{4-[(R)-2-amino-1-(4-trifluoromethylphenyl)ethyl]piperazin-1-yl}-5-(4-fluorophenyl)pyrimidin-4-ylamine

Guidance literature:: Multi-step reaction with 2 steps

1: dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; caesium carbonate / 1,4-dioxane; water / 100 °C / Sealed tube

2: Resolution of racemate

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; caesium carbonate; In 1,4-dioxane; water;