6-chloro-N-(1-methylpiperidin-3-yl)-4-(5-(phenylsulfonyl)-5H-pyrrolo[3,2-b]pyrazin-7-yl)pyridin-2-amine

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Chemical Name:6-chloro-N-(1-methylpiperidin-3-yl)-4-(5-(phenylsulfonyl)-5H-pyrrolo[3,2-b]pyrazin-7-yl)pyridin-2-amine
CAS No.:1262310-51-9
Molecular Formula:C₂₃H₂₃ClN₆O₂S
Molecular Weight:482.994
Hs Code.:

Synonyms:6-chloro-N-(1-methylpiperidin-3-yl)-4-(5-(phenylsulfonyl)-5H-pyrrolo[3,2-b]pyrazin-7-yl)pyridin-2-amine

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Chemical Property of 6-chloro-N-(1-methylpiperidin-3-yl)-4-(5-(phenylsulfonyl)-5H-pyrrolo[3,2-b]pyrazin-7-yl)pyridin-2-amine

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Technology Process of 6-chloro-N-(1-methylpiperidin-3-yl)-4-(5-(phenylsulfonyl)-5H-pyrrolo[3,2-b]pyrazin-7-yl)pyridin-2-amine

There total 7 articles about 6-chloro-N-(1-methylpiperidin-3-yl)-4-(5-(phenylsulfonyl)-5H-pyrrolo[3,2-b]pyrazin-7-yl)pyridin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 1262309-88-5
5-(phenylsulfonyl)-7-(trimethylstannyl)-5H-pyrrolo[2,3-b]pyrazine

: 6-chloro-4-iodo-N-(1-methylpiperidin-3-yl)pyridin-2-amine trifluoroacetate

: 1262310-51-9
6-chloro-N-(1-methylpiperidin-3-yl)-4-(5-(phenylsulfonyl)-5H-pyrrolo[3,2-b]pyrazin-7-yl)pyridin-2-amine

Guidance literature:: With cesium fluoride; bis(tri-t-butylphosphine)palladium⁽⁰⁾; In 1,4-dioxane; at 90 ℃; for 4h; Inert atmosphere;

Reference yield:

: 98027-84-0
2,6-dichloro-4-iodopyridine

: 1262310-51-9
6-chloro-N-(1-methylpiperidin-3-yl)-4-(5-(phenylsulfonyl)-5H-pyrrolo[3,2-b]pyrazin-7-yl)pyridin-2-amine

Guidance literature:: Multi-step reaction with 3 steps

1.1: 72 h / 120 °C / Sealed tube

1.2: 3 h / 20 °C

2.1: methanol / 0.17 h / 20 °C

2.2: 20 °C

3.1: cesium fluoride / bis(tri-t-butylphosphine)palladium⁽⁰⁾ / 1,4-dioxane / 4 h / 90 °C / Inert atmosphere

With cesium fluoride; bis(tri-t-butylphosphine)palladium⁽⁰⁾; In 1,4-dioxane; methanol;

Reference yield:

: 56015-31-7
7-bromo-5H-pyrrolo[2,3-b]pyrazine

: 1262310-51-9
6-chloro-N-(1-methylpiperidin-3-yl)-4-(5-(phenylsulfonyl)-5H-pyrrolo[3,2-b]pyrazin-7-yl)pyridin-2-amine

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydroxide / N,N-dimethyl-formamide / 0.33 h / 0 °C

1.2: 3 h / 20 °C

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 4 h / 115 °C / Inert atmosphere

3.1: cesium fluoride / bis(tri-t-butylphosphine)palladium⁽⁰⁾ / 1,4-dioxane / 4 h / 90 °C / Inert atmosphere

With cesium fluoride; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; bis(tri-t-butylphosphine)palladium⁽⁰⁾; In 1,4-dioxane; N,N-dimethyl-formamide; toluene;