3-Fluoro-5-bromobenzyl bromide

Base Information

• Chemical Name: 3-Fluoro-5-bromobenzyl bromide
• CAS No.: 216755-57-6
• Molecular Formula: C7H5Br2F
• Molecular Weight: 267.923
• Hs Code.: 2903999090
• Mol file: 216755-57-6.mol

Synonyms:3-Bromo-5-fluorobenzyl bromide 98%;

Chemical Property of 3-Fluoro-5-bromobenzyl bromide

Chemical Property:

• Vapor Pressure: 0.033mmHg at 25°C
• Melting Point: 47 °C
• Refractive Index: 1.583
• Boiling Point: 251.129 °C at 760 mmHg
• Flash Point: 105.679 °C
• PSA: 0.00000
• Density: 1.923 g/cm³
• LogP: 3.48310
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• Sensitive.: Lachrymatory
• Solubility.: soluble in Methanol
• Water Solubility.: Slightly soluble in water (2.9 g/L) (25°C).

Purity/Quality:

99% ^*data from raw suppliers

3-Bromo-5-fluorobenzyl Bromide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C
• Hazard Codes: C,T
• Statements: 25
• Safety Statements: 45

MSDS Files:

Useful:

• Uses: 3-Bromo-5-fluorobenzyl bromide is employed as a intermediate for pharmaceutical and chemical research.

Technology Process of 3-Fluoro-5-bromobenzyl bromide

There total 4 articles about 3-Fluoro-5-bromobenzyl bromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

5-fluoro-3-hydroxymethylbromobenzene (216755-56-5) → 1-bromo-3-(bromomethyl)-5-fluorobenzene (216755-57-6)

Guidance literature:

With carbon tetrabromide; triphenylphosphine; In dichloromethane; at 20 ℃;

Reference yield: 89.0%

1-bromo-3-fluoro-5-methylbenzene (202865-83-6) → 1-bromo-3-(bromomethyl)-5-fluorobenzene (216755-57-6)

Guidance literature:

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); In tetrachloromethane; Reflux;

DOI:10.1016/j.bmcl.2018.05.040

Reference yield: 66.0%

→ 1-bromo-3-(bromomethyl)-5-fluorobenzene (216755-57-6)

Guidance literature:

upstream raw materials:

5-fluoro-3-hydroxymethylbromobenzene

3-bromo-5-fluorobenzoic acid

1-bromo-3-fluoro-5-methylbenzene

Downstream raw materials:

tert-butyl 4-((3-bromo-5-fluorobenzyloxy)methyl)-4-phenylpiperidine-1-carboxylate

C₁₆H₂₁BrFNO₄

C₃₀H₄₀F₂N₂O₆

C₂₉H₃₈F₂N₂O₆