1-(p-chlorophenyl)-2-(methoxycarbonyl)-5,5-dimethyl-1,4-hexanedione

Base Information

• Chemical Name: 1-(p-chlorophenyl)-2-(methoxycarbonyl)-5,5-dimethyl-1,4-hexanedione
• CAS No.: 665006-37-1
• Molecular Formula: C₁₆H₁₉ClO₄
• Molecular Weight: 310.777
• Mol file: 665006-37-1.mol

Synonyms:1-(p-chlorophenyl)-2-(methoxycarbonyl)-5,5-dimethyl-1,4-hexanedione

Chemical Property of 1-(p-chlorophenyl)-2-(methoxycarbonyl)-5,5-dimethyl-1,4-hexanedione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(p-chlorophenyl)-2-(methoxycarbonyl)-5,5-dimethyl-1,4-hexanedione

There total 4 articles about 1-(p-chlorophenyl)-2-(methoxycarbonyl)-5,5-dimethyl-1,4-hexanedione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

diiodomethane (75-11-6) + Methyl 4,4-dimethyl-3-oxopentanoate (55107-14-7) + S-ethyl 4-chlorobenzenecarbothioate (28145-62-2) → 1-(p-chlorophenyl)-2-(methoxycarbonyl)-5,5-dimethyl-1,4-hexanedione (665006-37-1)

Guidance literature:

With diethylzinc; In dichloromethane;

DOI:10.1002/ejoc.200500387

Reference yield:

2-[(4-chloro-phenyl)-hydroxy-methyl]-5,5-dimethyl-4-oxo-hexanoic acid methyl ester → 1-(p-chlorophenyl)-2-(methoxycarbonyl)-5,5-dimethyl-1,4-hexanedione (665006-37-1)

Guidance literature:

With pyridinium chlorochromate; In dichloromethane;

DOI:10.1002/ejoc.200500387

Reference yield:

Methyl 4,4-dimethyl-3-oxopentanoate (55107-14-7) → 1-(p-chlorophenyl)-2-(methoxycarbonyl)-5,5-dimethyl-1,4-hexanedione (665006-37-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: Et₂Zn / CH₂Cl₂

1.2: CH₂Cl₂

2.1: PCC / CH₂Cl₂

With diethylzinc; pyridinium chlorochromate; In dichloromethane;

DOI:10.1002/ejoc.200500387

upstream raw materials:

diiodomethane

Methyl 4,4-dimethyl-3-oxopentanoate

S-ethyl 4-chlorobenzenecarbothioate

4-chlorobenzaldehyde

Downstream raw materials:

1-butyl-5-tert-butyl-2-(p-chlorophenyl)pyrrole-3-carboxylic acid

1-butyl-5-tert-butyl-2-(p-chlorophenyl)-3-(methoxycarbonyl)pyrrole

methyl 6-tert-butyl-3-(4-chlorophenyl)pyridazine-4-carboxylate