{9-[(2R,3R,4R,5R)-4-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-3-methoxy-5-([2,2';6',2'']terpyridin-4'-yloxymethyl)-tetrahydro-furan-2-yl]-9H-purin-6-yl}-[bis-(4-methoxy-phenyl)-phenyl-methyl]-amine

Base Information

• Chemical Name: {9-[(2R,3R,4R,5R)-4-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-3-methoxy-5-([2,2';6',2'']terpyridin-4'-yloxymethyl)-tetrahydro-furan-2-yl]-9H-purin-6-yl}-[bis-(4-methoxy-phenyl)-phenyl-methyl]-amine
• CAS No.: 222171-12-2
• Molecular Formula: C₆₈H₆₀N₈O₈
• Molecular Weight: 1117.27
• Mol file: 222171-12-2.mol

Synonyms:{9-[(2R,3R,4R,5R)-4-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-3-methoxy-5-([2,2';6',2'']terpyridin-4'-yloxymethyl)-tetrahydro-furan-2-yl]-9H-purin-6-yl}-[bis-(4-methoxy-phenyl)-phenyl-methyl]-amine

Chemical Property of {9-[(2R,3R,4R,5R)-4-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-3-methoxy-5-([2,2';6',2'']terpyridin-4'-yloxymethyl)-tetrahydro-furan-2-yl]-9H-purin-6-yl}-[bis-(4-methoxy-phenyl)-phenyl-methyl]-amine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of {9-[(2R,3R,4R,5R)-4-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-3-methoxy-5-([2,2';6',2'']terpyridin-4'-yloxymethyl)-tetrahydro-furan-2-yl]-9H-purin-6-yl}-[bis-(4-methoxy-phenyl)-phenyl-methyl]-amine

There total 5 articles about {9-[(2R,3R,4R,5R)-4-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-3-methoxy-5-([2,2';6',2'']terpyridin-4'-yloxymethyl)-tetrahydro-furan-2-yl]-9H-purin-6-yl}-[bis-(4-methoxy-phenyl)-phenyl-methyl]-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

4'-Chloro-2,2':6',2''-terpyridine (128143-89-5) + [(2R,3R,4R,5R)-3-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-5-(6-{[bis-(4-methoxy-phenyl)-phenyl-methyl]-amino}-purin-9-yl)-4-methoxy-tetrahydro-furan-2-yl]-methanol → {9-[(2R,3R,4R,5R)-4-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-3-methoxy-5-([2,2';6',2'']terpyridin-4'-yloxymethyl)-tetrahydro-furan-2-yl]-9H-purin-6-yl}-[bis-(4-methoxy-phenyl)-phenyl-methyl]-amine (222171-12-2)

Guidance literature:

With potassium hydroxide; In dimethyl sulfoxide; for 44h;

DOI:10.1039/a808522f

Reference yield:

{9-[4-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-5-(tert-butyl-dimethyl-silanyloxymethyl)-3-methoxy-tetrahydro-furan-2-yl]-9H-purin-6-yl}-[bis-(4-methoxy-phenyl)-phenyl-methyl]-amine (222171-09-7) → {9-[(2R,3R,4R,5R)-4-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-3-methoxy-5-([2,2';6',2'']terpyridin-4'-yloxymethyl)-tetrahydro-furan-2-yl]-9H-purin-6-yl}-[bis-(4-methoxy-phenyl)-phenyl-methyl]-amine (222171-12-2)

Guidance literature:

Multi-step reaction with 2 steps

1: n-Bu₄NF

2: KOH / dimethylsulfoxide

With potassium hydroxide; tetrabutyl ammonium fluoride; In dimethyl sulfoxide; 1: Hydrolysis / 2: Etherification;

DOI:10.1080/07328319908044769

Reference yield:

4,4'-dimethoxytrityl chloride (40615-36-9) → {9-[(2R,3R,4R,5R)-4-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-3-methoxy-5-([2,2';6',2'']terpyridin-4'-yloxymethyl)-tetrahydro-furan-2-yl]-9H-purin-6-yl}-[bis-(4-methoxy-phenyl)-phenyl-methyl]-amine (222171-12-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 77 percent / pyridine / 23 h

2: 99 percent / Bu₄NF / tetrahydrofuran / 0.5 h

3: 90 percent / KOH / dimethylsulfoxide / 44 h

With pyridine; potassium hydroxide; tetrabutyl ammonium fluoride; In tetrahydrofuran; dimethyl sulfoxide;

DOI:10.1039/a808522f

upstream raw materials:

4'-Chloro-2,2':6',2''-terpyridine

{9-[4-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-5-(tert-butyl-dimethyl-silanyloxymethyl)-3-methoxy-tetrahydro-furan-2-yl]-9H-purin-6-yl}-[bis-(4-methoxy-phenyl)-phenyl-methyl]-amine

4,4'-dimethoxytrityl chloride

2'-O-methyl adenosine

Downstream raw materials:

N-{9-[4-hydroxy-3-methoxy-5-([2,2';6',2'']terpyridin-4'-yloxymethyl)-tetrahydro-furan-2-yl]-9H-purin-6-yl}-benzamide