1,3-Dibromo-5-fluoro-2-methoxybenzene

Base Information

• Chemical Name: 1,3-Dibromo-5-fluoro-2-methoxybenzene
• CAS No.: 443-41-4
• Molecular Formula: C7H5Br2FO
• Molecular Weight: 283.923
• Hs Code.: 2909309090
• European Community (EC) Number: 610-177-1
• DSSTox Substance ID: DTXSID10378803
• Wikidata: Q82168375
• Mol file: 443-41-4.mol

Synonyms:1,3-dibromo-5-fluoro-2-methoxybenzene;443-41-4;2,6-Dibromo-4-fluoroanisole;1,3-Dibromo-5-fluoro-2-methoxy-benzene;SCHEMBL1163205;DTXSID10378803;VFAXMVDRHMXZSH-UHFFFAOYSA-N;BBL104155;MFCD00042231;STL557969;AKOS015834877;PS-10192;CS-0206158;FT-0610544;E89354;A826550

Chemical Property of 1,3-Dibromo-5-fluoro-2-methoxybenzene

Chemical Property:

• Vapor Pressure: 0.0202mmHg at 25°C
• Refractive Index: 1.557
• Boiling Point: 260.1 °C at 760 mmHg
• Flash Point: 132.1 °C
• PSA: 9.23000
• Density: 1.892 g/cm³
• LogP: 3.35930
• Storage Temp.: 2-8°C
• XLogP3: 3.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 283.86707
• Heavy Atom Count: 11
• Complexity: 122

Purity/Quality:

99%, ^*data from raw suppliers

1,3-Dibromo-5-fluoro-2-methoxybenzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=C(C=C(C=C1Br)F)Br

Technology Process of 1,3-Dibromo-5-fluoro-2-methoxybenzene

There total 3 articles about 1,3-Dibromo-5-fluoro-2-methoxybenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2,6-dibromo-4-fluorophenol (344-20-7) + dimethyl sulfate (77-78-1) → 1,3-dibromo-5-fluoro-2-methoxybenzene (443-41-4)

Guidance literature:

With potassium carbonate; In acetone; for 6h; Heating / reflux;

Reference yield:

2,6-dibromo-4-fluorophenol (344-20-7) → 1,3-dibromo-5-fluoro-2-methoxybenzene (443-41-4)

Guidance literature:

With CH₃I; potassium carbonate; In acetone;

Reference yield:

4-Fluorophenol (371-41-5) → 1,3-dibromo-5-fluoro-2-methoxybenzene (443-41-4)

Guidance literature:

Multi-step reaction with 2 steps

1: bromine / acetic acid / 20 °C

2: potassium carbonate / acetone / 6 h / 20 °C

With bromine; potassium carbonate; In acetic acid; acetone;

upstream raw materials:

2,6-dibromo-4-fluorophenol

dimethyl sulfate

4-Fluorophenol

Downstream raw materials:

2,6-dibromo-1,4-benzoquinone

2-(7-fluoro-4-methoxy-1-methyl-5-phenyl-1H-indol-3-yl)-N,N-dimethylacetamide

2,4-dibromo-6-fluoro-3-methoxyaniline

N-(2,4-dibromo-6-fluoro-3-methoxyphenyl)acetamide

Refernces

• 1、 -. "NOVEL PYRIMIDINE DERIVATIVES 698". Page/Page column 174. . Retrieved 2008/12/07.