(+)-(S)-O-(tert-butyldiphenylsilyl)-3-iodo-2-(benzyloxycarbonyl)aminopropan-1-ol

Base Information

Chemical Name:(+)-(S)-O-(tert-butyldiphenylsilyl)-3-iodo-2-(benzyloxycarbonyl)aminopropan-1-ol
CAS No.:128466-37-5
Molecular Formula:C₂₇H₃₂INO₃Si
Molecular Weight:573.546
Hs Code.:

Synonyms:(+)-(S)-O-(tert-butyldiphenylsilyl)-3-iodo-2-(benzyloxycarbonyl)aminopropan-1-ol

Suppliers and Price of (+)-(S)-O-(tert-butyldiphenylsilyl)-3-iodo-2-(benzyloxycarbonyl)aminopropan-1-ol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (+)-(S)-O-(tert-butyldiphenylsilyl)-3-iodo-2-(benzyloxycarbonyl)aminopropan-1-ol

Chemical Property:

Purity/Quality:

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Technology Process of (+)-(S)-O-(tert-butyldiphenylsilyl)-3-iodo-2-(benzyloxycarbonyl)aminopropan-1-ol

There total 7 articles about (+)-(S)-O-(tert-butyldiphenylsilyl)-3-iodo-2-(benzyloxycarbonyl)aminopropan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 128466-36-4
(+)-(S)-2-(benzyloxycarbonyl)amino-3-iodopropan-1-ol

: 58479-61-1
tert-butylchlorodiphenylsilane

: 128466-37-5
(+)-(S)-O-(tert-butyldiphenylsilyl)-3-iodo-2-(benzyloxycarbonyl)aminopropan-1-ol

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide;

Reference yield:

: 1676-81-9
N-benzyloxycarbonyl-L-serine methyl ester

: 128466-37-5
(+)-(S)-O-(tert-butyldiphenylsilyl)-3-iodo-2-(benzyloxycarbonyl)aminopropan-1-ol

Guidance literature:: Multi-step reaction with 5 steps

1: 100 percent / p-toluenesulfonic acid monohydrate / benzene / 1 h / Heating

2: 100 percent / CaCl₂, NaBH₄ / tetrahydrofuran; ethanol / 3 h / 5 °C

3: 79 percent / triphenylphosphine, imidazole, iodine / benzene; acetonitrile / 1.5 h / Heating

4: 99 percent / conc. HCl / acetone / 16 h / Ambient temperature

5: 90 percent / imidazole / dimethylformamide / 1 h / Ambient temperature

With 1H-imidazole; hydrogenchloride; sodium tetrahydroborate; iodine; toluene-4-sulfonic acid; triphenylphosphine; calcium chloride; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; acetone; acetonitrile; benzene;
DOI:10.1016/S0040-4020(01)96112-5

Reference yield:

: 128466-45-5
(R)-4-hydroxymethyl-2,2-dimethyloxazolidine-3-carboxylic acid benzyl ester

: 128466-37-5
(+)-(S)-O-(tert-butyldiphenylsilyl)-3-iodo-2-(benzyloxycarbonyl)aminopropan-1-ol

Guidance literature:: Multi-step reaction with 3 steps

1: 79 percent / triphenylphosphine, imidazole, iodine / benzene; acetonitrile / 1.5 h / Heating

2: 99 percent / conc. HCl / acetone / 16 h / Ambient temperature

3: 90 percent / imidazole / dimethylformamide / 1 h / Ambient temperature

With 1H-imidazole; hydrogenchloride; iodine; triphenylphosphine; In N,N-dimethyl-formamide; acetone; acetonitrile; benzene;
DOI:10.1016/S0040-4020(01)96112-5