{2-[5-(3-chlorophenyl)-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrrolo[3,4-d]pyrimidin-6-yl]ethyl}carbamic acid tert-butyl ester

Base Information

Chemical Name:{2-[5-(3-chlorophenyl)-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrrolo[3,4-d]pyrimidin-6-yl]ethyl}carbamic acid tert-butyl ester
CAS No.:1613623-72-5
Molecular Formula:C₂₁H₂₅ClN₄O₄
Molecular Weight:432.907
Hs Code.:

Synonyms:{2-[5-(3-chlorophenyl)-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrrolo[3,4-d]pyrimidin-6-yl]ethyl}carbamic acid tert-butyl ester

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Chemical Property of {2-[5-(3-chlorophenyl)-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrrolo[3,4-d]pyrimidin-6-yl]ethyl}carbamic acid tert-butyl ester

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Technology Process of {2-[5-(3-chlorophenyl)-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrrolo[3,4-d]pyrimidin-6-yl]ethyl}carbamic acid tert-butyl ester

There total 7 articles about {2-[5-(3-chlorophenyl)-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrrolo[3,4-d]pyrimidin-6-yl]ethyl}carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 108-37-2
1-bromo-3-chlorobenzene

: 1613623-71-4
(6-(2-((tert-butoxycarbonyl)amino)ethyl)-1,3-dimethyl-2,4-dioxo-2,3,4,6-tetrahydro-1H-pyrrolo[3,4-d]pyrimidin-5-yl)boronic acid

: 1613623-72-5
{2-[5-(3-chlorophenyl)-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrrolo[3,4-d]pyrimidin-6-yl]ethyl}carbamic acid tert-butyl ester

Guidance literature:: With [1,1'-bis(di-tert-butylphosphino)ferrocene]palladium(II) dichloride; potassium carbonate; In acetic acid butyl ester; water; at 8 ℃; for 4h; Inert atmosphere; Micellar solution;

Reference yield:

: C₇H₁₄ClNO₄S

: 1613623-72-5
{2-[5-(3-chlorophenyl)-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrrolo[3,4-d]pyrimidin-6-yl]ethyl}carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: ruthenium(III) trichloride hydrate; sodium periodate / acetonitrile / 1 h / 0 °C

2.1: sodium hydride / mineral oil; tetrahydrofuran / 0.42 h / 0 - 20 °C / Inert atmosphere

2.2: 0 °C / Inert atmosphere

3.1: lithium diisopropyl amide / tetrahydrofuran / 0.3 h / -78 °C / Inert atmosphere

3.2: 2.03 h / -78 °C / Inert atmosphere

4.1: [1,1'-bis(di-tert-butylphosphino)ferrocene]palladium(II) dichloride; potassium carbonate / water; acetic acid butyl ester / 4 h / 8 °C / Inert atmosphere; Micellar solution

With sodium periodate; ruthenium(III) trichloride hydrate; [1,1'-bis(di-tert-butylphosphino)ferrocene]palladium(II) dichloride; sodium hydride; potassium carbonate; lithium diisopropyl amide; In tetrahydrofuran; acetic acid butyl ester; water; acetonitrile; mineral oil; 4.1: |Suzuki Coupling;

Reference yield:

: 874-14-6,156398-76-4
1,3-dimethyluracil

: 1613623-72-5
{2-[5-(3-chlorophenyl)-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrrolo[3,4-d]pyrimidin-6-yl]ethyl}carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: 2-methyltetrahydrofuran / 0.08 h / 30 °C / Inert atmosphere

1.2: 1.25 h / 0 - 5 °C / Inert atmosphere

2.1: sodium hydride / mineral oil; tetrahydrofuran / 0.42 h / 0 - 20 °C / Inert atmosphere

2.2: 0 °C / Inert atmosphere

3.1: lithium diisopropyl amide / tetrahydrofuran / 0.3 h / -78 °C / Inert atmosphere

3.2: 2.03 h / -78 °C / Inert atmosphere

4.1: [1,1'-bis(di-tert-butylphosphino)ferrocene]palladium(II) dichloride; potassium carbonate / water; acetic acid butyl ester / 4 h / 8 °C / Inert atmosphere; Micellar solution

With [1,1'-bis(di-tert-butylphosphino)ferrocene]palladium(II) dichloride; sodium hydride; potassium carbonate; lithium diisopropyl amide; In tetrahydrofuran; 2-methyltetrahydrofuran; acetic acid butyl ester; water; mineral oil; 4.1: |Suzuki Coupling;