10-(5-chlorofuran-2-yl)-5-(3-chlorophenyl)-1,3-dimethyl-7,8,9,10-tetrahydropyrazino[1',2':1,2]pyrrolo[3,4-d]pyrimidine-2,4(1H,3H)-dione

Base Information

Chemical Name:10-(5-chlorofuran-2-yl)-5-(3-chlorophenyl)-1,3-dimethyl-7,8,9,10-tetrahydropyrazino[1',2':1,2]pyrrolo[3,4-d]pyrimidine-2,4(1H,3H)-dione
CAS No.:1613622-30-2
Molecular Formula:C₂₁H₁₈Cl₂N₄O₃
Molecular Weight:445.305
Hs Code.:

Synonyms:10-(5-chlorofuran-2-yl)-5-(3-chlorophenyl)-1,3-dimethyl-7,8,9,10-tetrahydropyrazino[1',2':1,2]pyrrolo[3,4-d]pyrimidine-2,4(1H,3H)-dione

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Chemical Property of 10-(5-chlorofuran-2-yl)-5-(3-chlorophenyl)-1,3-dimethyl-7,8,9,10-tetrahydropyrazino[1',2':1,2]pyrrolo[3,4-d]pyrimidine-2,4(1H,3H)-dione

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Technology Process of 10-(5-chlorofuran-2-yl)-5-(3-chlorophenyl)-1,3-dimethyl-7,8,9,10-tetrahydropyrazino[1',2':1,2]pyrrolo[3,4-d]pyrimidine-2,4(1H,3H)-dione

There total 6 articles about 10-(5-chlorofuran-2-yl)-5-(3-chlorophenyl)-1,3-dimethyl-7,8,9,10-tetrahydropyrazino[1',2':1,2]pyrrolo[3,4-d]pyrimidine-2,4(1H,3H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 21508-19-0
5-chloro-2-furaldehyde

: 1613622-31-3
6-(2-aminoethyl)-5-(3-chlorophenyl)-1,3-dimethyl-1,6-dihydropyrrolo[3,4-d]pyrimidine-2,4-dione

: 1613622-30-2
10-(5-chlorofuran-2-yl)-5-(3-chlorophenyl)-1,3-dimethyl-7,8,9,10-tetrahydropyrazino[1',2':1,2]pyrrolo[3,4-d]pyrimidine-2,4(1H,3H)-dione

Guidance literature:: 5-chloro-2-furaldehyde; 6-(2-aminoethyl)-5-(3-chlorophenyl)-1,3-dimethyl-1,6-dihydropyrrolo[3,4-d]pyrimidine-2,4-dione; In ethanol; at 50 ℃; for 1h; Microwave irradiation;

With trifluoroacetic acid; In ethanol; at 60 ℃; for 0.5h; Microwave irradiation;

Reference yield:

: 1613623-71-4
(6-(2-((tert-butoxycarbonyl)amino)ethyl)-1,3-dimethyl-2,4-dioxo-2,3,4,6-tetrahydro-1H-pyrrolo[3,4-d]pyrimidin-5-yl)boronic acid

: 1613622-30-2
10-(5-chlorofuran-2-yl)-5-(3-chlorophenyl)-1,3-dimethyl-7,8,9,10-tetrahydropyrazino[1',2':1,2]pyrrolo[3,4-d]pyrimidine-2,4(1H,3H)-dione

Guidance literature:: Multi-step reaction with 3 steps

1.1: [1,1'-bis(di-tert-butylphosphino)ferrocene]palladium(II) dichloride; potassium carbonate / water; acetic acid butyl ester / 4 h / 8 °C / Inert atmosphere; Micellar solution

2.1: trifluoroacetic acid / dichloromethane / 2 h / Inert atmosphere

3.1: ethanol / 1 h / 50 °C / Microwave irradiation

3.2: 0.5 h / 60 °C / Microwave irradiation

With [1,1'-bis(di-tert-butylphosphino)ferrocene]palladium(II) dichloride; potassium carbonate; trifluoroacetic acid; In ethanol; dichloromethane; acetic acid butyl ester; water; 1.1: |Suzuki Coupling;

Reference yield:

: 1613623-72-5
{2-[5-(3-chlorophenyl)-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrrolo[3,4-d]pyrimidin-6-yl]ethyl}carbamic acid tert-butyl ester

: 1613622-30-2
10-(5-chlorofuran-2-yl)-5-(3-chlorophenyl)-1,3-dimethyl-7,8,9,10-tetrahydropyrazino[1',2':1,2]pyrrolo[3,4-d]pyrimidine-2,4(1H,3H)-dione

Guidance literature:: Multi-step reaction with 2 steps

1.1: trifluoroacetic acid / dichloromethane / 2 h / Inert atmosphere

2.1: ethanol / 1 h / 50 °C / Microwave irradiation

2.2: 0.5 h / 60 °C / Microwave irradiation

With trifluoroacetic acid; In ethanol; dichloromethane;