N-{(7R)-6-cyano-7-(4-cyanophenyl)-5-methyl-4-[3-(trifluoromethyl)phenyl]-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidin-2-yl}methanesulfonamide

Base Information

Chemical Name:N-{(7R)-6-cyano-7-(4-cyanophenyl)-5-methyl-4-[3-(trifluoromethyl)phenyl]-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidin-2-yl}methanesulfonamide
CAS No.:1234619-90-9
Molecular Formula:C₂₂H₁₆F₃N₇O₂S
Molecular Weight:499.476
Hs Code.:

Synonyms:N-{(7R)-6-cyano-7-(4-cyanophenyl)-5-methyl-4-[3-(trifluoromethyl)phenyl]-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidin-2-yl}methanesulfonamide

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Chemical Property of N-{(7R)-6-cyano-7-(4-cyanophenyl)-5-methyl-4-[3-(trifluoromethyl)phenyl]-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidin-2-yl}methanesulfonamide

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Technology Process of N-{(7R)-6-cyano-7-(4-cyanophenyl)-5-methyl-4-[3-(trifluoromethyl)phenyl]-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidin-2-yl}methanesulfonamide

There total 9 articles about N-{(7R)-6-cyano-7-(4-cyanophenyl)-5-methyl-4-[3-(trifluoromethyl)phenyl]-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidin-2-yl}methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 1234619-40-9
benzyl {(7R)-6-cyano-7-(4-cyanophenyl)-5-methyl-4-[3-(trifluoromethyl)phenyl]-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidin-2-yl}(methylsulfonyl)carbamate

: 1234619-90-9
N-{(7R)-6-cyano-7-(4-cyanophenyl)-5-methyl-4-[3-(trifluoromethyl)phenyl]-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidin-2-yl}methanesulfonamide

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In methanol; at 20 ℃; for 0.5h; under 760.051 Torr;

Reference yield:

: 1234619-70-5
benzyl {(7R)-6-cyano-7-(4-cyanophenyl)-5-methyl-4-[3-(trifluoromethyl)phenyl]-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidin-2-yl}carbamate

: 1234619-90-9
N-{(7R)-6-cyano-7-(4-cyanophenyl)-5-methyl-4-[3-(trifluoromethyl)phenyl]-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidin-2-yl}methanesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine; pyridine / tetrahydrofuran / 12 h / 20 °C / Inert atmosphere

2: hydrogen / palladium 10% on activated carbon / methanol / 0.5 h / 20 °C / 760.05 Torr

With pyridine; hydrogen; triethylamine; palladium 10% on activated carbon; In tetrahydrofuran; methanol;

Reference yield:

: 1234737-79-1
(7R)-2-amino-7-(4-cyanophenyl)-5-methyl-4-[3-(trifluoromethyl)phenyl]-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidine-6-carbonitrile

: 1234619-90-9
N-{(7R)-6-cyano-7-(4-cyanophenyl)-5-methyl-4-[3-(trifluoromethyl)phenyl]-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidin-2-yl}methanesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / 12 h / 0 - 20 °C / Inert atmosphere

2: triethylamine; pyridine / tetrahydrofuran / 12 h / 20 °C / Inert atmosphere

3: hydrogen / palladium 10% on activated carbon / methanol / 0.5 h / 20 °C / 760.05 Torr

With pyridine; hydrogen; triethylamine; palladium 10% on activated carbon; In tetrahydrofuran; methanol;