Technology Process of {4-[2-(4-fluoro-phenyl)-pyrrolidin-1-yl]-pyridin-2-yl}-urea
There total 5 articles about {4-[2-(4-fluoro-phenyl)-pyrrolidin-1-yl]-pyridin-2-yl}-urea which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: triethylamine / dimethyl sulfoxide / 1.17 h / 120 - 200 °C / Microwave irradiation
2: lithium hexamethyldisilazane / CyJohnPhos; tris-(dibenzylideneacetone)dipalladium(0) / tetrahydrofuran / 22 h / 65 °C / Inert atmosphere
3: dichloromethane / 16 h / 50 °C / Sealed tube
4: potassium carbonate; ethanol / 0.75 h / 80 °C
With
ethanol; potassium carbonate; triethylamine; lithium hexamethyldisilazane;
tris-(dibenzylideneacetone)dipalladium(0); CyJohnPhos;
In
tetrahydrofuran; dichloromethane; dimethyl sulfoxide;
- Guidance literature:
-
With
ethanol; potassium carbonate;
at 80 ℃;
for 0.75h;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: triethylamine / dimethyl sulfoxide / 1.17 h / 120 - 200 °C / Microwave irradiation
2: lithium hexamethyldisilazane / CyJohnPhos; tris-(dibenzylideneacetone)dipalladium(0) / tetrahydrofuran / 22 h / 65 °C / Inert atmosphere
3: dichloromethane / 16 h / 50 °C / Sealed tube
4: potassium carbonate; ethanol / 0.75 h / 80 °C
With
ethanol; potassium carbonate; triethylamine; lithium hexamethyldisilazane;
tris-(dibenzylideneacetone)dipalladium(0); CyJohnPhos;
In
tetrahydrofuran; dichloromethane; dimethyl sulfoxide;