2-bromo-5-(3,6,6-trimethyl-4-oxo-4,5,6,7-tetrahydroindazol-2-yl)benzonitrile

Base Information

Chemical Name:2-bromo-5-(3,6,6-trimethyl-4-oxo-4,5,6,7-tetrahydroindazol-2-yl)benzonitrile
CAS No.:1392213-68-1
Molecular Formula:C₁₇H₁₆BrN₃O
Molecular Weight:358.238
Hs Code.:

Synonyms:2-bromo-5-(3,6,6-trimethyl-4-oxo-4,5,6,7-tetrahydroindazol-2-yl)benzonitrile

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Chemical Property of 2-bromo-5-(3,6,6-trimethyl-4-oxo-4,5,6,7-tetrahydroindazol-2-yl)benzonitrile

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Technology Process of 2-bromo-5-(3,6,6-trimethyl-4-oxo-4,5,6,7-tetrahydroindazol-2-yl)benzonitrile

There total 1 articles about 2-bromo-5-(3,6,6-trimethyl-4-oxo-4,5,6,7-tetrahydroindazol-2-yl)benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 19.0%

: 16315-16-5
3,6,6-trimethyl-1⁽²⁾,5,6,7-tetrahydro-4H-indazole-4-one

: 57381-39-2
2-bromo-5-fluorobenzonitrile

: 1392213-68-1
2-bromo-5-(3,6,6-trimethyl-4-oxo-4,5,6,7-tetrahydroindazol-2-yl)benzonitrile

: 1392213-66-9
2-bromo-5-(3,6,6-trimethyl-4-oxo-4,5,6,7-tetrahydroindazol-1-yl)-benzonitrile

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 20 - 80 ℃;
DOI:10.1039/c2ob25852h

Reference yield: 54.0%

: 1392213-68-1
2-bromo-5-(3,6,6-trimethyl-4-oxo-4,5,6,7-tetrahydroindazol-2-yl)benzonitrile

: 189440-33-3
(2-aminoethyl)bis(2-pyridylmethyl)amine

: 1392213-69-2
C₃₁H₃₃N₇O

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; palladium dichloride; sodium t-butanolate; In toluene; at 100 ℃; Inert atmosphere;
DOI:10.1039/c2ob25852h

Reference yield:

: 1392213-68-1
2-bromo-5-(3,6,6-trimethyl-4-oxo-4,5,6,7-tetrahydroindazol-2-yl)benzonitrile

: 1392213-64-7
2-((2-[bis(pyridin-2-ylmethyl)amino]ethyl)amino)-5-(3,6,6-trimethyl-4-oxo-4,5,6,7-tetrahydroindazol-2-yl)benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; palladium dichloride; sodium t-butanolate / toluene / 100 °C / Inert atmosphere

2: dihydrogen peroxide; potassium hydroxide / ethanol; dimethyl sulfoxide / 4 h / 50 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; dihydrogen peroxide; potassium hydroxide; palladium dichloride; sodium t-butanolate; In ethanol; dimethyl sulfoxide; toluene; 1: Buchwald-Hartwig coupling;
DOI:10.1039/c2ob25852h