3-{N-(3-tert-butoxycarbonylamino-propyl)-N'-[4-methyl-2-(3-phenyl-propionylamino)-pentanoyl]-hydrazinocarbonyl}-acrylic acid ethyl ester

Base Information

Chemical Name:3-{N-(3-tert-butoxycarbonylamino-propyl)-N'-[4-methyl-2-(3-phenyl-propionylamino)-pentanoyl]-hydrazinocarbonyl}-acrylic acid ethyl ester
CAS No.:685543-87-7
Molecular Formula:C₂₉H₄₄N₄O₇
Molecular Weight:560.691
Hs Code.:

3-{<i>N</i>-(3-<i>tert</i>-butoxycarbonylamino-propyl)-<i>N</i>'-[4-methyl-2-(3-phenyl-propionylamino)-pentanoyl]-hydrazinocarbonyl}-acrylic acid ethyl ester

Synonyms:3-{N-(3-tert-butoxycarbonylamino-propyl)-N'-[4-methyl-2-(3-phenyl-propionylamino)-pentanoyl]-hydrazinocarbonyl}-acrylic acid ethyl ester

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Chemical Property of 3-{N-(3-tert-butoxycarbonylamino-propyl)-N'-[4-methyl-2-(3-phenyl-propionylamino)-pentanoyl]-hydrazinocarbonyl}-acrylic acid ethyl ester

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Technology Process of 3-{N-(3-tert-butoxycarbonylamino-propyl)-N'-[4-methyl-2-(3-phenyl-propionylamino)-pentanoyl]-hydrazinocarbonyl}-acrylic acid ethyl ester

There total 6 articles about 3-{N-(3-tert-butoxycarbonylamino-propyl)-N'-[4-methyl-2-(3-phenyl-propionylamino)-pentanoyl]-hydrazinocarbonyl}-acrylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 14.0%

: 2459-05-4
(E)-4-ethoxy-4-oxobut-2-enoic acid

: 863647-62-5
(3-{N'-[4-methyl-2-(3-phenyl-propionylamino)-pentanoyl]-hydrazino}-propyl)-carbamic acid tert-butyl ester

: 685543-87-7
3-{N-(3-tert-butoxycarbonylamino-propyl)-N'-[4-methyl-2-(3-phenyl-propionylamino)-pentanoyl]-hydrazinocarbonyl}-acrylic acid ethyl ester

Guidance literature:: With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1021/jm049938j

Reference yield:

: 58885-58-8
N-tert-butoxycarbonyl-3-aminopropanol

: 685543-87-7
3-{N-(3-tert-butoxycarbonylamino-propyl)-N'-[4-methyl-2-(3-phenyl-propionylamino)-pentanoyl]-hydrazinocarbonyl}-acrylic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 67 percent / iodooxybenzoic acid / dimethylsulfoxide / 5 h / 20 °C

2: 82 percent / ethanol / 20 °C

3: 59 percent / NaBH₃CN; acetic acid / tetrahydrofuran / 20 °C

4: 14 percent / HOBt; EDC / dimethylformamide / 20 °C

With sodium cyanoborohydride; benzotriazol-1-ol; acetic acid; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In tetrahydrofuran; ethanol; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/jm049938j

Reference yield:

: 58885-60-2
N-(tert-butoxycarbonyl)-3-aminopropanal

: 685543-87-7
3-{N-(3-tert-butoxycarbonylamino-propyl)-N'-[4-methyl-2-(3-phenyl-propionylamino)-pentanoyl]-hydrazinocarbonyl}-acrylic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 82 percent / ethanol / 20 °C

2: 59 percent / NaBH₃CN; acetic acid / tetrahydrofuran / 20 °C

3: 14 percent / HOBt; EDC / dimethylformamide / 20 °C

With sodium cyanoborohydride; benzotriazol-1-ol; acetic acid; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm049938j