N-de-tert-butoxycarbonyl-N-[2-(1,1,1-trifluoro-2-methyl)-propyloxycarbonyl]docetaxel

Base Information

• Chemical Name: N-de-tert-butoxycarbonyl-N-[2-(1,1,1-trifluoro-2-methyl)-propyloxycarbonyl]docetaxel
• CAS No.: 154044-50-5
• Molecular Formula: C₄₃H₅₀F₃NO₁₄
• Molecular Weight: 861.864
• Mol file: 154044-50-5.mol

Synonyms:N-de-tert-butoxycarbonyl-N-[2-(1,1,1-trifluoro-2-methyl)-propyloxycarbonyl]docetaxel

Chemical Property of N-de-tert-butoxycarbonyl-N-[2-(1,1,1-trifluoro-2-methyl)-propyloxycarbonyl]docetaxel

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-de-tert-butoxycarbonyl-N-[2-(1,1,1-trifluoro-2-methyl)-propyloxycarbonyl]docetaxel

There total 3 articles about N-de-tert-butoxycarbonyl-N-[2-(1,1,1-trifluoro-2-methyl)-propyloxycarbonyl]docetaxel which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

N-de-tert-butoxycarbonyl-N-[2-(1,1,1-trifluoro-2-methyl)-propyloxycarbonyl]-7,10-di(2,2,2-trichloroethyloxycarbonyl)-docetaxel (154044-59-4) → N-de-tert-butoxycarbonyl-N-[2-(1,1,1-trifluoro-2-methyl)-propyloxycarbonyl]docetaxel (154044-50-5)

Guidance literature:

With acetic acid; zinc; In methanol; at 50 ℃; for 0.5h;

DOI:10.1016/j.ejmech.2008.04.004

Reference yield:

C13H11F3N2O3 + (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-acetoxy-9-(((2R,3S)-3-amino-2-hydroxy-3-phenylpropanoyl)oxy)-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxet-12-yl benzoate (133524-69-3,133577-36-3,133577-37-4) → N-de-tert-butoxycarbonyl-N-[2-(1,1,1-trifluoro-2-methyl)-propyloxycarbonyl]docetaxel (154044-50-5)

Guidance literature:

With pyridine; at 20 ℃; Inert atmosphere;

Reference yield:

Docetaxel (114915-20-7,114977-28-5,114977-29-6,133577-32-9,133577-33-0) → N-de-tert-butoxycarbonyl-N-[2-(1,1,1-trifluoro-2-methyl)-propyloxycarbonyl]docetaxel (154044-50-5)

Guidance literature:

Multi-step reaction with 2 steps

1: formic acid / 4 h / 20 °C

2: pyridine / 20 °C / Inert atmosphere

With pyridine; formic acid;

upstream raw materials:

N-de-tert-butoxycarbonyl-N-[2-(1,1,1-trifluoro-2-methyl)-propyloxycarbonyl]-7,10-di(2,2,2-trichloroethyloxycarbonyl)-docetaxel

(2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-acetoxy-9-(((2R,3S)-3-amino-2-hydroxy-3-phenylpropanoyl)oxy)-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxet-12-yl benzoate

Docetaxel