4-pyrrolidin-1-yl-piperidine-1-carboxylic acid [5-(4-chloro-2-methylphenyl)-2H-pyrazol-3-yl]amide

Base Information

• Chemical Name: 4-pyrrolidin-1-yl-piperidine-1-carboxylic acid [5-(4-chloro-2-methylphenyl)-2H-pyrazol-3-yl]amide
• CAS No.: 1608129-65-2
• Molecular Formula: C₂₀H₂₆ClN₅O
• Molecular Weight: 387.912
• Mol file: 1608129-65-2.mol

Synonyms:4-pyrrolidin-1-yl-piperidine-1-carboxylic acid [5-(4-chloro-2-methylphenyl)-2H-pyrazol-3-yl]amide

Chemical Property of 4-pyrrolidin-1-yl-piperidine-1-carboxylic acid [5-(4-chloro-2-methylphenyl)-2H-pyrazol-3-yl]amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-pyrrolidin-1-yl-piperidine-1-carboxylic acid [5-(4-chloro-2-methylphenyl)-2H-pyrazol-3-yl]amide

There total 5 articles about 4-pyrrolidin-1-yl-piperidine-1-carboxylic acid [5-(4-chloro-2-methylphenyl)-2H-pyrazol-3-yl]amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C19H22ClN3O4 (1608129-80-1) + 4-(1-pyrrolidinyl)piperidine (5004-07-9) → 4-pyrrolidinylpiperidine-1-carboxylic acid tert-butyl ester (902837-26-7) + 4-pyrrolidin-1-yl-piperidine-1-carboxylic acid [5-(4-chloro-2-methylphenyl)-2H-pyrazol-3-yl]amide (1608129-65-2)

Guidance literature:

In 1,4-dioxane; at 60 ℃; for 6h;

DOI:10.1016/j.ejmech.2014.03.031

Reference yield:

4-chloro-2-methylbenzoic acid (7499-07-2) → 4-pyrrolidin-1-yl-piperidine-1-carboxylic acid [5-(4-chloro-2-methylphenyl)-2H-pyrazol-3-yl]amide (1608129-65-2)

Guidance literature:

Multi-step reaction with 6 steps

1: sulfuric acid / Reflux

2: n-butyllithium / acetonitrile; toluene; hexane / 0.33 h / -78 - 20 °C / Inert atmosphere

3: hydrazine hydrate / ethanol / 18 h / Reflux

4: potassium hydroxide / water; dichloromethane / 48 h / 20 °C

5: sodium hydroxide / water; dichloromethane / 48 h / 0 - 20 °C

6: 1,4-dioxane / 6 h / 60 °C

With n-butyllithium; sulfuric acid; hydrazine hydrate; potassium hydroxide; sodium hydroxide; In 1,4-dioxane; ethanol; hexane; dichloromethane; water; toluene; acetonitrile;

DOI:10.1016/j.ejmech.2014.03.031

Reference yield:

3-(4-chloro-2-methylphenyl)-3-oxopropanenitrile (1205055-78-2) → 4-pyrrolidin-1-yl-piperidine-1-carboxylic acid [5-(4-chloro-2-methylphenyl)-2H-pyrazol-3-yl]amide (1608129-65-2)

Guidance literature:

Multi-step reaction with 4 steps

1: hydrazine hydrate / ethanol / 18 h / Reflux

2: potassium hydroxide / water; dichloromethane / 48 h / 20 °C

3: sodium hydroxide / water; dichloromethane / 48 h / 0 - 20 °C

4: 1,4-dioxane / 6 h / 60 °C

With hydrazine hydrate; potassium hydroxide; sodium hydroxide; In 1,4-dioxane; ethanol; dichloromethane; water;

DOI:10.1016/j.ejmech.2014.03.031

upstream raw materials:

4-chloro-2-methylbenzoic acid

3-(4-chloro-2-methylphenyl)-3-oxopropanenitrile

C₁₉H₂₂ClN₃O₄

4-(1-pyrrolidinyl)piperidine