5-tert-butyl-1-[3-hydroxy-4-(N-phenylbenzimidazol-2-yl)phenyl]-4,4-dimethyl-2,6,7-trioxabicyclo[3.2.0]heptane

Base Information

Chemical Name:5-tert-butyl-1-[3-hydroxy-4-(N-phenylbenzimidazol-2-yl)phenyl]-4,4-dimethyl-2,6,7-trioxabicyclo[3.2.0]heptane
CAS No.:1426250-66-9
Molecular Formula:C₂₉H₃₀N₂O₄
Molecular Weight:470.568
Hs Code.:

Synonyms:5-tert-butyl-1-[3-hydroxy-4-(N-phenylbenzimidazol-2-yl)phenyl]-4,4-dimethyl-2,6,7-trioxabicyclo[3.2.0]heptane

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Chemical Property of 5-tert-butyl-1-[3-hydroxy-4-(N-phenylbenzimidazol-2-yl)phenyl]-4,4-dimethyl-2,6,7-trioxabicyclo[3.2.0]heptane

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Technology Process of 5-tert-butyl-1-[3-hydroxy-4-(N-phenylbenzimidazol-2-yl)phenyl]-4,4-dimethyl-2,6,7-trioxabicyclo[3.2.0]heptane

There total 4 articles about 5-tert-butyl-1-[3-hydroxy-4-(N-phenylbenzimidazol-2-yl)phenyl]-4,4-dimethyl-2,6,7-trioxabicyclo[3.2.0]heptane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1426250-61-4
4-tert-butyl-5-[3-hydroxy-4-(N-phenylbenzimidazol-2-yl)phenyl]-3,3-dimethyl-2,3-dihydrofuran

: 1426250-66-9
5-tert-butyl-1-[3-hydroxy-4-(N-phenylbenzimidazol-2-yl)phenyl]-4,4-dimethyl-2,6,7-trioxabicyclo[3.2.0]heptane

Guidance literature:: With oxygen; 5,15,10,20-tetraphenylporphyrin; In acetone; at 0 ℃; for 1.5h; Irradiation;
DOI:10.3987/COM-12-12602

Reference yield:

: 5-(4-bromo-3-methoxyphenyl)-4-tert-butyl-3,3-dimethyl-2,3-dihydrofuran

: 1426250-66-9
5-tert-butyl-1-[3-hydroxy-4-(N-phenylbenzimidazol-2-yl)phenyl]-4,4-dimethyl-2,6,7-trioxabicyclo[3.2.0]heptane

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-butyllithium / hexane; tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

1.2: Inert atmosphere

2.1: trifluoromethylsulfonic anhydride; Triphenylphosphine oxide / dichloromethane / 20 °C / Inert atmosphere

3.1: sodium thiomethoxide / N,N-dimethyl-formamide / 0.5 h / 20 - 140 °C / Inert atmosphere

4.1: 5,15,10,20-tetraphenylporphyrin; oxygen / acetone / 1.5 h / 0 °C / Irradiation

With n-butyllithium; trifluoromethylsulfonic anhydride; oxygen; 5,15,10,20-tetraphenylporphyrin; Triphenylphosphine oxide; sodium thiomethoxide; In tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide; acetone;
DOI:10.3987/COM-12-12602

Reference yield:

: 244124-41-2
5-(4-carboxy-3-methoxyphenyl)-4-tert-butyl-3,3-dimethyl-2,3-dihydrofuran

: 1426250-66-9
5-tert-butyl-1-[3-hydroxy-4-(N-phenylbenzimidazol-2-yl)phenyl]-4,4-dimethyl-2,6,7-trioxabicyclo[3.2.0]heptane

Guidance literature:: Multi-step reaction with 3 steps

1: trifluoromethylsulfonic anhydride; Triphenylphosphine oxide / dichloromethane / 20 °C / Inert atmosphere

2: sodium thiomethoxide / N,N-dimethyl-formamide / 0.5 h / 20 - 140 °C / Inert atmosphere

3: 5,15,10,20-tetraphenylporphyrin; oxygen / acetone / 1.5 h / 0 °C / Irradiation

With trifluoromethylsulfonic anhydride; oxygen; 5,15,10,20-tetraphenylporphyrin; Triphenylphosphine oxide; sodium thiomethoxide; In dichloromethane; N,N-dimethyl-formamide; acetone;
DOI:10.3987/COM-12-12602