2-hydroxy-4-oxo-4-p-bromophenylbut-2-enoic acid ethyl ester

Base Information

• Chemical Name: 2-hydroxy-4-oxo-4-p-bromophenylbut-2-enoic acid ethyl ester
• CAS No.: 1221821-65-3
• Molecular Formula: C₁₂H₁₁BrO₄
• Molecular Weight: 299.121
• Mol file: 1221821-65-3.mol

Synonyms:2-hydroxy-4-oxo-4-p-bromophenylbut-2-enoic acid ethyl ester

Chemical Property of 2-hydroxy-4-oxo-4-p-bromophenylbut-2-enoic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-hydroxy-4-oxo-4-p-bromophenylbut-2-enoic acid ethyl ester

There total 1 articles about 2-hydroxy-4-oxo-4-p-bromophenylbut-2-enoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

para-bromoacetophenone (99-90-1) + oxalic acid diethyl ester (95-92-1) → 2-hydroxy-4-oxo-4-p-bromophenylbut-2-enoic acid ethyl ester (1221821-65-3)

Guidance literature:

With sodium ethanolate; In ethanol; at 50 ℃; for 3h; Reflux;

DOI:10.1016/j.bmc.2012.10.029

Reference yield: 93.0%

2-hydroxy-4-oxo-4-p-bromophenylbut-2-enoic acid ethyl ester (1221821-65-3) → ethyl 5-(4-bromophenyl)-5-hydroxy-4,5-dihydro-3-isoxazolecarboxylate (1221821-71-1) + ethyl 5-(4-bromophenyl)-3-hydroxy-2,3-dihydro-3-isoxazolecarboxylate (1221821-76-6) + ethyl 5-(4-bromo-phenyl)-isoxazole-3-carboxylate (33277-15-5)

Guidance literature:

With hydroxylamine hydrochloride; N-ethyl-N,N-diisopropylamine; In ethanol; for 2h; Reflux;

DOI:10.2174/157017810790533922

Reference yield: 85.0%

2-hydroxy-4-oxo-4-p-bromophenylbut-2-enoic acid ethyl ester (1221821-65-3) → ethyl 5-(4-bromo-phenyl)-isoxazole-3-carboxylate (33277-15-5)

Guidance literature:

With hydroxylamine hydrochloride; In ethanol; for 2h; Reflux;

DOI:10.1016/j.bmc.2011.04.057

upstream raw materials:

para-bromoacetophenone

oxalic acid diethyl ester

Downstream raw materials:

ethyl 5-(4-bromophenyl)-5-hydroxy-4,5-dihydro-3-isoxazolecarboxylate

ethyl 5-(4-bromophenyl)-3-hydroxy-2,3-dihydro-3-isoxazolecarboxylate

ethyl 5-(4-bromo-phenyl)-isoxazole-3-carboxylate

5-(4-bromo-phenyl)-isoxazole-3-carboxylic acid