11-<<2-<(styrylsulfonyl)amino>ethyl>thio>-6,11-dihydrodibenzoxepin-2-carboxylic acid methyl ester

Base Information

• Chemical Name: 11-<<2-<(styrylsulfonyl)amino>ethyl>thio>-6,11-dihydrodibenzoxepin-2-carboxylic acid methyl ester
• CAS No.: 142424-08-6
• Molecular Formula: C₂₆H₂₅NO₅S₂
• Molecular Weight: 495.62
• Mol file: 142424-08-6.mol

Synonyms:11-<<2-<(styrylsulfonyl)amino>ethyl>thio>-6,11-dihydrodibenzoxepin-2-carboxylic acid methyl ester

Chemical Property of 11-<<2-<(styrylsulfonyl)amino>ethyl>thio>-6,11-dihydrodibenzoxepin-2-carboxylic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 11-<<2-<(styrylsulfonyl)amino>ethyl>thio>-6,11-dihydrodibenzoxepin-2-carboxylic acid methyl ester

There total 4 articles about 11-<<2-<(styrylsulfonyl)amino>ethyl>thio>-6,11-dihydrodibenzoxepin-2-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

11-<(2-aminoethyl)thio>-6,11-dihydrobenzoxepin-2-carboxylic acid methyl ester (105359-99-7) + β-styrenesulfonyl chloride (4091-26-3) → 11-<<2-<(styrylsulfonyl)amino>ethyl>thio>-6,11-dihydrodibenzoxepin-2-carboxylic acid methyl ester (142424-08-6)

Guidance literature:

With triethylamine; In dichloromethane; for 3h; Ambient temperature;

DOI:10.1021/jm00096a016

Reference yield:

methyl 11-oxo-6,11-dihydrodibenz[b,e]oxepin-2-carboxylate (79669-87-7) → 11-<<2-<(styrylsulfonyl)amino>ethyl>thio>-6,11-dihydrodibenzoxepin-2-carboxylic acid methyl ester (142424-08-6)

Guidance literature:

Multi-step reaction with 4 steps

1: NaBH₄ / methanol

2: p-toluenesulfonic acid

3: 96 percent / BF₃*Et₂O / CH₂Cl₂ / 3 h / Ambient temperature

4: 62 percent / Et₃N / CH₂Cl₂ / 3 h / Ambient temperature

With sodium tetrahydroborate; boron trifluoride diethyl etherate; toluene-4-sulfonic acid; triethylamine; In methanol; dichloromethane;

DOI:10.1021/jm00096a016

Reference yield:

methyl 6,11-dihydro-11-hydroxydibenz[b,e]oxepin-2-carboxylate (79669-90-2) → 11-<<2-<(styrylsulfonyl)amino>ethyl>thio>-6,11-dihydrodibenzoxepin-2-carboxylic acid methyl ester (142424-08-6)

Guidance literature:

Multi-step reaction with 3 steps

1: p-toluenesulfonic acid

2: 96 percent / BF₃*Et₂O / CH₂Cl₂ / 3 h / Ambient temperature

3: 62 percent / Et₃N / CH₂Cl₂ / 3 h / Ambient temperature

With boron trifluoride diethyl etherate; toluene-4-sulfonic acid; triethylamine; In dichloromethane;

DOI:10.1021/jm00096a016

upstream raw materials:

11-<(2-aminoethyl)thio>-6,11-dihydrobenzoxepin-2-carboxylic acid methyl ester

β-styrenesulfonyl chloride

methyl 11-oxo-6,11-dihydrodibenz[b,e]oxepin-2-carboxylate

methyl 6,11-dihydro-11-hydroxydibenz[b,e]oxepin-2-carboxylate

Downstream raw materials:

(+)-11-<<2-<(styrylsulfonyl)amino>ethyl>thio>-6,11-dihydrodibenzoxepin-2-carboxylic acid (trimethylsilyl)ethyl ester

(-)-11-<<2-<(styrylsulfonyl)amino>ethyl>thio>-6,11-dihydrodibenzoxepin-2-carboxylic acid (trimethylsilyl)ethyl ester

(+/-)-11-<<2-<(styrylsulfonyl)amino>ethyl>thio>-6,11-dihydrodibenzoxepin-2-carboxylic acid

(+)-11-<<2-<(styrylsulfonyl)amino>ethyl>thio>-6,11-dihydrodibenzoxepin-2-carboxylic acid