4091-26-3

Usage

Uses

Used in Pharmaceutical Industry:
BETA-STYRENE SULFONYL CHLORIDE is used as a key intermediate for the synthesis of various pharmaceuticals. Its ability to introduce the sulfonyl chloride functional group allows for the development of a wide range of medicinal compounds with specific therapeutic properties.
Used in Agrochemical Industry:
In the agrochemical sector, BETA-STYRENE SULFONYL CHLORIDE is employed as a crucial building block for the production of agrochemicals. Its reactivity and utility in organic synthesis contribute to the creation of effective compounds for agricultural applications, such as pesticides and herbicides.
Used in Organic Synthesis:
BETA-STYRENE SULFONYL CHLORIDE is utilized as a versatile reagent in organic synthesis for the introduction of the sulfonyl chloride functional group into organic molecules. This allows for the synthesis of a diverse array of organic compounds with various applications in different industries.
Used in Chemical Research:
In the field of chemical research, BETA-STYRENE SULFONYL CHLORIDE serves as an important tool for studying the reactivity and properties of sulfonyl chloride functional groups. Its use in various chemical transformations aids in understanding the underlying mechanisms and developing new synthetic methodologies.

InChI:InChI=1/C8H7ClO2S/c9-12(10,11)7-6-8-4-2-1-3-5-8/h1-7H/b7-6+

Upstream product

• 29184-38-1 2-Chlor-2-phenyl-ethansulfonylchlorid 
• 109880-31-1 (E)-2-Phenyl-ethenesulfonic acid 4-benzyloxy-phenyl ester 
• 100-42-5 styrene 

Downstream Products

• 108676-48-8 4-methyl-2-(2-phenyl-ethenesulfonylamino)-thiazole-5-sulfonic acid amide 
• 35943-63-6 X 
• 55129-79-8 N-(Styrylsulfonyl)-benzamidin 
• 4363-41-1 2-phenyleth-1-ene-1-sulfonamide 
• 13719-33-0 (E)-2-Phenyl-ethenesulfonic acid m-tolyl ester 
• 109880-30-0 (E)-2-Phenyl-ethenesulfonic acid 4-methoxy-phenyl ester 
• 405-18-5 2-phenylethenesulfonyl fluoride 
• 13719-37-4 2-phenyl-ethenesulfonic acid 4-chlorophenyl ester 

Relevant academic research and scientific papers

[3+2] Cycloaddition of an Azomethyne Ylide and Vinyl Sulfonyl Fluorides ― an Approach to Pyrrolidine-3-sulfonyl Fluorides

[3+2] Cycloaddition reactions of vinyl sulfonyl fluorides with an in-situ generated nonstabilized azomethine ylide is described for the first time. The resulting pyrrolidine-3-sulfonyl fluorides were obtained in 50–83 % yield on a scale of up to 25 g. Their utility as reagents for sulfur(VI)–fluoride exchange (SuFEx) and some other transformations was also demonstrated.

Systematic variation of the benzenesulfonamide part of the GluN2A selective NMDA receptor antagonist TCN-201

GluN2A subunit containing N-methyl-D-aspartate receptors (NMDARs) are highly involved in various physiological processes in the central nervous system, but also in some diseases, such as anxiety, depression and schizophrenia. However, the role of GluN2A subunit containing NMDARs in pathological processes is not exactly elucidated. In order to obtain potent and selective inhibitors of GluN2A subunit containing NMDARs, the selective negative allosteric modulator 2 was systematically modified at the benzenesulfonamide part. The activity of the test compounds was recorded in two electrode voltage clamp experiments using Xenopus laevis oocytes expressing exclusively NMDARs with GluN1a and GluN2A subunits. It was found that halogen atoms in 3-position of the benzenesulfonamide part result in high GluN2A antagonistic activity. With an IC50 value of 204?nM the 3-bromo derivative 5i (N-{4-[(2-benzoylhydrazino)carbonyl]benzyl}-3-bromobenzenesulfonamide) has 2.5-fold higher antagonistic activity than the lead compound 2 and represents our new lead compound.