1-(p-toluenesulfonyl)cyclopropanol

Base Information

• Chemical Name: 1-(p-toluenesulfonyl)cyclopropanol
• CAS No.: 1006613-83-7
• Molecular Formula: C₁₀H₁₂O₃S
• Molecular Weight: 212.269
• Mol file: 1006613-83-7.mol

Synonyms:1-(p-toluenesulfonyl)cyclopropanol

Chemical Property of 1-(p-toluenesulfonyl)cyclopropanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(p-toluenesulfonyl)cyclopropanol

There total 1 articles about 1-(p-toluenesulfonyl)cyclopropanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

1-ethoxy-1-cyclopropanol (13837-45-1) + sodium 4-methylbenzenesulfinate (824-79-3) → 1-(p-toluenesulfonyl)cyclopropanol (1006613-83-7)

Guidance literature:

With formic acid; In methanol; water; at 20 ℃; for 48h;

DOI:10.1016/j.tetlet.2007.11.093

Reference yield: 83.0%

1-(p-toluenesulfonyl)cyclopropanol (1006613-83-7) + 4-n-methylphenylacetylene (766-97-2) → 1-(p-Tolylethynyl)cyclopropanol (60512-43-8)

Guidance literature:

4-n-methylphenylacetylene; With n-butyllithium; In tetrahydrofuran; at -30 ℃; for 0.5h;

1-(p-toluenesulfonyl)cyclopropanol; In tetrahydrofuran; at -30 ℃; for 2h; Further stages.;

DOI:10.1016/j.tetlet.2008.03.041

Reference yield: 80.0%

1-(p-toluenesulfonyl)cyclopropanol (1006613-83-7) + 2-phenyl-2-(2-propynyloxymethyl)-1,3-dioxalane (76089-32-2) → C16H18O4

Guidance literature:

2-phenyl-2-(2-propynyloxymethyl)-1,3-dioxalane; With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 0.833333h; Inert atmosphere;

1-(p-toluenesulfonyl)cyclopropanol; In tetrahydrofuran; at -78 - 20 ℃; for 8h; Inert atmosphere;

DOI:10.1002/adsc.202001167

upstream raw materials:

1-ethoxy-1-cyclopropanol

sodium 4-methylbenzenesulfinate

Downstream raw materials:

1-(phenylethynyl)cyclopropan-1-ol

1-(p-Tolylethynyl)cyclopropanol

Refernces