5-(4-methoxyphenyl)uridine-5′-triphosphate

Base Information

• Chemical Name: 5-(4-methoxyphenyl)uridine-5′-triphosphate
• CAS No.: 1300529-55-8
• Molecular Formula: C₁₆H₂₁N₂O₁₆P₃
• Molecular Weight: 590.268
• Mol file: 1300529-55-8.mol

Synonyms:5-(4-methoxyphenyl)uridine-5′-triphosphate

Chemical Property of 5-(4-methoxyphenyl)uridine-5′-triphosphate

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-(4-methoxyphenyl)uridine-5′-triphosphate

There total 4 articles about 5-(4-methoxyphenyl)uridine-5′-triphosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

4-methoxyphenylboronic acid (5720-07-0) + 5-Iodo-UTP (34198-43-1,73202-51-4,80160-19-6) → 5-(4-methoxyphenyl)uridine-5′-triphosphate (1300529-55-8)

Guidance literature:

With sodium tetrachloropalladate(II); trisodium tris(3-sulfophenyl)phosphine; caesium carbonate; In water; at 60 ℃; for 1h; Inert atmosphere;

DOI:10.1039/c3ob40485d

Reference yield:

5-iodouridine (1024-99-3) → 5-(4-methoxyphenyl)uridine-5′-triphosphate (1300529-55-8)

Guidance literature:

Multi-step reaction with 4 steps

1: trichlorophosphate / acetone / 4 h / -5 °C / Inert atmosphere

2: triphenylphosphine; 2,2'-dipyridyldisulphide / dimethyl sulfoxide / 1 h / 20 °C

3: tributyl-amine; 1H-tetrazole; potassium pyrophosphate / N,N-dimethyl-formamide / 5 h / 20 °C

4: trisodium tris(3-sulfophenyl)phosphine; sodium tetrachloropalladate(II); caesium carbonate / water / 1 h / 60 °C / Inert atmosphere

With 1H-tetrazole; potassium pyrophosphate; sodium tetrachloropalladate(II); 2,2'-dipyridyldisulphide; tributyl-amine; trisodium tris(3-sulfophenyl)phosphine; caesium carbonate; triphenylphosphine; trichlorophosphate; In water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetone; 4: |Suzuki-Miyaura Coupling;

DOI:10.1039/c3ob40485d

Reference yield:

5-iodouridine-5′-monophosphate (21016-94-4,7531-46-6) → 5-(4-methoxyphenyl)uridine-5′-triphosphate (1300529-55-8)

Guidance literature:

Multi-step reaction with 3 steps

1: triphenylphosphine; 2,2'-dipyridyldisulphide / dimethyl sulfoxide / 1 h / 20 °C

2: tributyl-amine; 1H-tetrazole; potassium pyrophosphate / N,N-dimethyl-formamide / 5 h / 20 °C

3: trisodium tris(3-sulfophenyl)phosphine; sodium tetrachloropalladate(II); caesium carbonate / water / 1 h / 60 °C / Inert atmosphere

With 1H-tetrazole; potassium pyrophosphate; sodium tetrachloropalladate(II); 2,2'-dipyridyldisulphide; tributyl-amine; trisodium tris(3-sulfophenyl)phosphine; caesium carbonate; triphenylphosphine; In water; dimethyl sulfoxide; N,N-dimethyl-formamide; 3: |Suzuki-Miyaura Coupling;

DOI:10.1039/c3ob40485d

upstream raw materials:

5-iodouridine

5-iodouridine-5′-monophosphate

4-methoxyphenylboronic acid

5-Iodo-UTP

Downstream raw materials:

5-(4-methoxyphenyl)-UDP-Gal