86393-34-2

Basic information

• Product Name: 2,4-Dichloro-5-fluorobenzoyl chloride
• Synonyms: 2,4-DICHLORO-5-FLUOROBENZOYL CHLORIDE;2,4-Dichloro-5-Fluorosbenzoylchloride;2,4-difluoro-5-fluorobenzoyl chloride;2,4-DICHLORO-5-FLUOROBENZOYL CHLORIDE, 9 6%;2,4-Dichloro-5-fluorobenzoyl chloride 98%;2,4-Dichloro-5-fluorobenzoylchloride98%;5-FLUORO2,4-DICHLOROBENZOYLCHLORIDE;2,4-Dichlor-5-fluor-benzoylchlorid
• CAS NO: 86393-34-2
• Molecular Formula: C₇H₂Cl₃FO
• Molecular Weight: 227.45
• EINECS: 428-390-1
• Product Categories: Chlorobenzene Series;Acid Halides;Carbonyl Compounds;Organic Building Blocks;Fluorine series
• Mol File: 86393-34-2.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 143-144 °C35 mm Hg(lit.)
• Flash Point: >230 °F
• Appearance: Colorless to pale yellow liquid
• Density: 1.568 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.0309mmHg at 25°C
• Refractive Index: n20/D 1.572(lit.)
• Sensitive: Moisture Sensitive
• BRN: 4989077
• CAS DataBase Reference: 2,4-Dichloro-5-fluorobenzoyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-Dichloro-5-fluorobenzoyl chloride(86393-34-2)
• EPA Substance Registry System: 2,4-Dichloro-5-fluorobenzoyl chloride(86393-34-2)

Safety Data

• Hazard Codes: C
• Statements: 34-36/37
• Safety Statements: 26-27-28-36/37/39-45
• RIDADR: UN 3265 8/PG 2
• WGK Germany: 1
• HazardClass: 8
• PackingGroup: II
• Hazardous Substances Data: 86393-34-2(Hazardous Substances Data)

Usage

Chemical Properties

Colorless transparent liquid

InChI:InChI=1/C7H2Cl3FO/c8-4-2-5(9)6(11)1-3(4)7(10)12/h1-2H

Upstream product

• 56-23-5 tetrachloromethane 
• 1435-48-9 1,3-dichloro-4-fluorobenzene 
• 124-38-9 carbon dioxide 
• 704-10-9 2,4-dichloro-5-fluoroacetophenone 
• 86522-89-6 2,4-dichloro-5-fluoro-benzoic acid 

Downstream Products

• 1028202-69-8 ethyl 3-(benzothiazol-2-yl)-4-(2,4-dichloro-5-fluorophenyl)-2,4-dioxobutanoate 
• 103318-75-8 2,4-Dichloro-5-fluorobenzoic acid ethyl ester 
• 105392-26-5 3-Cyclopropylamino-2-(2,4-dichlor-5-fluorbenzoyl)acrylsaeure-methylester 
• 106648-05-9 2-(2,4-Dichlor-5-fluorbenzoyl)-3-ethylaminoacrylsaeure-ethylester 
• 138998-51-3 2-(2,4-Dichlor-5-fluorbenzoyl)-3-methylaminoacrylsaeure-ethylester 

Relevant articles and documents

Br?nsted acid-catalyzed chlorination of aromatic carboxylic acids

The chlorination of aromatic carboxylic acids with SOCl2 has been effectively performed by reacting with a Br?nsted acid as the catalyst. Based on this discovery, an efficient catalytic method that is cheaper than traditional catalytic methods was developed. 20 substrates were chlorinated offering excellent yields in a short reaction time. And the SOCl2/Br?nsted acid system has been used in a larger scale preparative reaction. A dual activation mechanism was proposed to prove the irreplaceable system of SOCl2/Br?nsted acid.

Quinolone derivatives and preparation method and application thereof

The invention relates to quinolone derivatives and a preparation method and application thereof. According to the invention, the structure of quinolone is modified, a substituent group on a nitrogenatom at the position 1 is derived, a diphenyl ether structural unit with biological activity is introduced, and meanwhile, the position 3, the position 6 and the position 7 of a main ring are properlychanged to form the novel quinolone derivatives. A quinolone compound structure is innovated, a bioactive molecule splicing method is adopted, and the diphenyl ether structural unit is introduced into quinolone molecules through C-N bonds to prepare a series of the novel quinolone derivatives are prepared, so the range of the structure is expanded; in addition, the quinolone derivatives preparedby the invention have antibacterial activity and antitumor activity, and are expected to be expanded in application range; an efficient acid-binding agent and an efficient catalyst are introduced, anda one-pot technology is adopted, so preparation of the series of derivatives is successfully achieved, separation and purification of intermediate products are avoided, reaction procedures are reduced, reaction time is greatly shortened, and the production efficiency is improved.

Synthesis method of 2,4-dichloro-5-fluorobenzoyl chloride

The invention relates to a synthesis method of a quinolone drug intermediate 2,4-dichloro-5-fluorobenzoyl chloride. The synthesis method comprises: preparing 2,4-dichloro-5-fluorobenzoyl chloride from2,4-dichlorofluorobenzene, carbon dioxide and carbon tetrachloride under the action of a cationic resin catalyst. According to the present invention, with the synthesis method, the problems of too long process route, complex post-treatment, high requirement on equipment, use of highly toxic chemicals, low yield, poor product quality and the like unsuitable for industrial production are solved; and the synthesis method of the present invention has advantages of inexpensive and easily-available raw materials, short process route, good production safety, easy separation of the catalyst, less emission of waste acid, simple post-treatment, high yield and good product quality, and is suitable for industrial continuous production.