(1S)-2-[2-({[(2Z)-3-butyl[1,3]thiazolo[4,5-c]pyridin-2(3H)-ylidene]amino}carbonyl)-4-(trifluoromethyl)phenoxy]-1-methylethyl N-(tert-butoxycarbonyl)-2-methylalaninate

Base Information

Chemical Name:(1S)-2-[2-({[(2Z)-3-butyl[1,3]thiazolo[4,5-c]pyridin-2(3H)-ylidene]amino}carbonyl)-4-(trifluoromethyl)phenoxy]-1-methylethyl N-(tert-butoxycarbonyl)-2-methylalaninate
CAS No.:1311319-02-4
Molecular Formula:C₃₀H₃₇F₃N₄O₆S
Molecular Weight:638.708
Hs Code.:

(1S)-2-[2-({[(2Z)-3-butyl[1,3]thiazolo[4,5-c]pyridin-2(3H)-ylidene]amino}carbonyl)-4-(trifluoromethyl)phenoxy]-1-methylethyl N-(tert-butoxycarbonyl)-2-methylalaninate

Synonyms:(1S)-2-[2-({[(2Z)-3-butyl[1,3]thiazolo[4,5-c]pyridin-2(3H)-ylidene]amino}carbonyl)-4-(trifluoromethyl)phenoxy]-1-methylethyl N-(tert-butoxycarbonyl)-2-methylalaninate

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Chemical Property of (1S)-2-[2-({[(2Z)-3-butyl[1,3]thiazolo[4,5-c]pyridin-2(3H)-ylidene]amino}carbonyl)-4-(trifluoromethyl)phenoxy]-1-methylethyl N-(tert-butoxycarbonyl)-2-methylalaninate

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Technology Process of (1S)-2-[2-({[(2Z)-3-butyl[1,3]thiazolo[4,5-c]pyridin-2(3H)-ylidene]amino}carbonyl)-4-(trifluoromethyl)phenoxy]-1-methylethyl N-(tert-butoxycarbonyl)-2-methylalaninate

There total 5 articles about (1S)-2-[2-({[(2Z)-3-butyl[1,3]thiazolo[4,5-c]pyridin-2(3H)-ylidene]amino}carbonyl)-4-(trifluoromethyl)phenoxy]-1-methylethyl N-(tert-butoxycarbonyl)-2-methylalaninate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 30992-29-1
Boc-Aib-OH

: 1231955-18-2
N-[(2Z)-3-butyl[1,3]thiazolo[4,5-c]pyridin-2(3H)-ylidene]-2-{[(2S)-2-hydroxypropyl]oxy}-5-(trifluoromethyl)benzamide

: 1311319-02-4
(1S)-2-[2-({[(2Z)-3-butyl[1,3]thiazolo[4,5-c]pyridin-2(3H)-ylidene]amino}carbonyl)-4-(trifluoromethyl)phenoxy]-1-methylethyl N-(tert-butoxycarbonyl)-2-methylalaninate

Guidance literature:: With dmap; triethylamine; HATU; In N,N-dimethyl-formamide; at 50 ℃;

Reference yield:

: 1232169-35-5,1311319-13-7
2-fluoro-N-(thiazolo[4,5-c]pyridin-2-yl)-5-(trifluoromethyl)benzamide

: 1311319-02-4
(1S)-2-[2-({[(2Z)-3-butyl[1,3]thiazolo[4,5-c]pyridin-2(3H)-ylidene]amino}carbonyl)-4-(trifluoromethyl)phenoxy]-1-methylethyl N-(tert-butoxycarbonyl)-2-methylalaninate

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate; tetra-(n-butyl)ammonium iodide; tetraethylammonium iodide / toluene / 12 h / Reflux

2.1: sodium hydride / tetrahydrofuran / 0.33 h / 20 °C

2.2: 4 h / 20 °C

3.1: dmap; triethylamine; HATU / N,N-dimethyl-formamide / 50 °C

With dmap; tetraethylammonium iodide; tetra(n-butyl)ammonium hydrogensulfate; tetra-(n-butyl)ammonium iodide; sodium hydride; potassium carbonate; triethylamine; HATU; In tetrahydrofuran; N,N-dimethyl-formamide; toluene;

Reference yield:

: 89786-54-9
thiazolo[4,5-c]pyridine-2-ylamine

: 1311319-02-4
(1S)-2-[2-({[(2Z)-3-butyl[1,3]thiazolo[4,5-c]pyridin-2(3H)-ylidene]amino}carbonyl)-4-(trifluoromethyl)phenoxy]-1-methylethyl N-(tert-butoxycarbonyl)-2-methylalaninate

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / ethyl acetate; tetrahydrofuran / 12 h / 20 °C

2.1: tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate; tetra-(n-butyl)ammonium iodide; tetraethylammonium iodide / toluene / 12 h / Reflux

3.1: sodium hydride / tetrahydrofuran / 0.33 h / 20 °C

3.2: 4 h / 20 °C

4.1: dmap; triethylamine; HATU / N,N-dimethyl-formamide / 50 °C

With dmap; tetraethylammonium iodide; tetra(n-butyl)ammonium hydrogensulfate; tetra-(n-butyl)ammonium iodide; sodium hydride; potassium carbonate; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine; HATU; In tetrahydrofuran; ethyl acetate; N,N-dimethyl-formamide; toluene;