5-(4-methoxy-phenyl)-6,7,8,9-tetrahydro-2H-11-thia-2,4,10-triaza-benzo[b]fluorene-1-thione

Base Information

• Chemical Name: 5-(4-methoxy-phenyl)-6,7,8,9-tetrahydro-2H-11-thia-2,4,10-triaza-benzo[b]fluorene-1-thione
• CAS No.: 499142-24-4
• Molecular Formula: C₂₀H₁₇N₃OS₂
• Molecular Weight: 379.506

Synonyms:5-(4-methoxy-phenyl)-6,7,8,9-tetrahydro-2H-11-thia-2,4,10-triaza-benzo[b]fluorene-1-thione

Chemical Property of 5-(4-methoxy-phenyl)-6,7,8,9-tetrahydro-2H-11-thia-2,4,10-triaza-benzo[b]fluorene-1-thione

Chemical Property:

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Technology Process of 5-(4-methoxy-phenyl)-6,7,8,9-tetrahydro-2H-11-thia-2,4,10-triaza-benzo[b]fluorene-1-thione

There total 2 articles about 5-(4-methoxy-phenyl)-6,7,8,9-tetrahydro-2H-11-thia-2,4,10-triaza-benzo[b]fluorene-1-thione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

1-chloro-5-(4-methoxy-phenyl)-6,7,8,9-tetrahydro-11-thia-2,4,10-triaza-benzo[b]fluorene (906375-68-6) → 5-(4-methoxy-phenyl)-6,7,8,9-tetrahydro-2H-11-thia-2,4,10-triaza-benzo[b]fluorene-1-thione (499142-24-4)

Guidance literature:

1-chloro-5-(4-methoxy-phenyl)-6,7,8,9-tetrahydro-11-thia-2,4,10-triaza-benzo[b]fluorene; With thiourea; In N,N-dimethyl-formamide; for 3h; Heating;

With sodium hydroxide; water;

DOI:10.1002/jccs.200500136

Reference yield:

3-Amino-4-(4-methoxy-phenyl)-5,6,7,8-tetrahydro-thieno[2,3-b]quinoline-2-carboxylic acid amide (117601-32-8) → 5-(4-methoxy-phenyl)-6,7,8,9-tetrahydro-2H-11-thia-2,4,10-triaza-benzo[b]fluorene-1-thione (499142-24-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 92 percent / acetic anhydride / 4 h / Heating

2.1: 83 percent / phosphorus oxychloride / 4 h / Heating

3.1: thiourea / dimethylformamide / 3 h / Heating

3.2: 77 percent / NaOH; water

With acetic anhydride; thiourea; trichlorophosphate; In N,N-dimethyl-formamide;

DOI:10.1002/jccs.200500136

Reference yield: 84.0%

5-(4-methoxy-phenyl)-6,7,8,9-tetrahydro-2H-11-thia-2,4,10-triaza-benzo[b]fluorene-1-thione (499142-24-4) + methyl iodide (74-88-4) → 5-(4-methoxy-phenyl)-1-methylsulfanyl-6,7,8,9-tetrahydro-11-thia-2,4,10-triaza-benzo[b]fluorene (667886-74-0)

Guidance literature:

With sodium acetate; In ethanol; for 2h; Heating;

DOI:10.1002/jccs.200500136

upstream raw materials:

1-chloro-5-(4-methoxy-phenyl)-6,7,8,9-tetrahydro-11-thia-2,4,10-triaza-benzo[b]fluorene

3-Amino-4-(4-methoxy-phenyl)-5,6,7,8-tetrahydro-thieno[2,3-b]quinoline-2-carboxylic acid amide

Downstream raw materials:

5-(4-methoxy-phenyl)-1-methylsulfanyl-6,7,8,9-tetrahydro-11-thia-2,4,10-triaza-benzo[b]fluorene

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