(R)-4-{3-hydroxy-2-[4-(3-hydroxypropyl)-2-methoxyphenoxy]-propyl}-2-methoxyphenol

Base Information

• Chemical Name: (R)-4-{3-hydroxy-2-[4-(3-hydroxypropyl)-2-methoxyphenoxy]-propyl}-2-methoxyphenol
• CAS No.: 1335126-28-7
• Molecular Formula: C₂₀H₂₆O₆
• Molecular Weight: 362.423

Synonyms:(R)-4-{3-hydroxy-2-[4-(3-hydroxypropyl)-2-methoxyphenoxy]-propyl}-2-methoxyphenol

Chemical Property of (R)-4-{3-hydroxy-2-[4-(3-hydroxypropyl)-2-methoxyphenoxy]-propyl}-2-methoxyphenol

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Technology Process of (R)-4-{3-hydroxy-2-[4-(3-hydroxypropyl)-2-methoxyphenoxy]-propyl}-2-methoxyphenol

There total 4 articles about (R)-4-{3-hydroxy-2-[4-(3-hydroxypropyl)-2-methoxyphenoxy]-propyl}-2-methoxyphenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

(R)-3-[4-({1-(benzyloxy)-3-[4-(benzyloxy)-3-methoxyphenyl]-propan-2-yl}oxy)-3-methoxyphenyl]propan-1-ol → (R)-4-{3-hydroxy-2-[4-(3-hydroxypropyl)-2-methoxyphenoxy]-propyl}-2-methoxyphenol (1335126-28-7)

Guidance literature:

With 10 wt% Pd(OH)2 on carbon; hydrogen; In ethanol; at 20 ℃; for 6h; under 1034.32 Torr;

DOI:10.1055/s-0037-1611919

Reference yield:

ligraminol E 4-O-β-D-xyloside → D-xylose (58-86-6) + (R)-4-{3-hydroxy-2-[4-(3-hydroxypropyl)-2-methoxyphenoxy]-propyl}-2-methoxyphenol (1335126-28-7)

Guidance literature:

With hydrogenchloride; water; for 2h; Reflux;

DOI:10.1021/np4005322

Reference yield:

(S)-1-(benzyloxy)-3-[4-(benzyloxy)-3-methoxyphenyl]propan-2-ol → (R)-4-{3-hydroxy-2-[4-(3-hydroxypropyl)-2-methoxyphenoxy]-propyl}-2-methoxyphenol (1335126-28-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere

2.1: dimethylsulfide borane complex / tetrahydrofuran / 2.5 h / 0 - 20 °C / Inert atmosphere

2.2: 1.5 h / 0 °C / Inert atmosphere

3.1: 10 wt% Pd(OH)2 on carbon; hydrogen / ethanol / 6 h / 20 °C / 1034.32 Torr

With di-isopropyl azodicarboxylate; dimethylsulfide borane complex; 10 wt% Pd(OH)2 on carbon; hydrogen; triphenylphosphine; In tetrahydrofuran; ethanol; 1.1: |Mitsunobu Displacement;

DOI:10.1055/s-0037-1611919

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