Technology Process of 3-cyclopentyl-4-(cis-4-hydroxycyclohexyl)furan-2,5-dione
There total 13 articles about 3-cyclopentyl-4-(cis-4-hydroxycyclohexyl)furan-2,5-dione which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogenchloride;
In
ethanol;
at 50 ℃;
for 5h;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: toluene-4-sulfonic acid / acetone; water / 15 h / 55 °C
2.1: methanol; sodium tetrahydroborate / 2 h / 0 °C
3.1: 1H-imidazole / N,N-dimethyl-formamide / 15 h / 65 °C
4.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / 1.5 h / -78 - 0 °C / Inert atmosphere
4.2: 1 h / -78 °C
5.1: palladium 10% on activated carbon; hydrogen / ethanol / 24 h / Inert atmosphere
6.1: acetic anhydride / 15 h / 130 °C
7.1: hydrogenchloride / ethanol / 5 h / 50 °C
With
1H-imidazole; hydrogenchloride; methanol; sodium tetrahydroborate; n-butyllithium; palladium 10% on activated carbon; hydrogen; acetic anhydride; toluene-4-sulfonic acid; diisopropylamine;
In
tetrahydrofuran; ethanol; hexane; water; N,N-dimethyl-formamide; acetone;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: methanol; sodium tetrahydroborate / 2 h / 0 °C
2.1: 1H-imidazole / N,N-dimethyl-formamide / 15 h / 65 °C
3.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / 1.5 h / -78 - 0 °C / Inert atmosphere
3.2: 1 h / -78 °C
4.1: palladium 10% on activated carbon; hydrogen / ethanol / 24 h / Inert atmosphere
5.1: acetic anhydride / 15 h / 130 °C
6.1: hydrogenchloride / ethanol / 5 h / 50 °C
With
1H-imidazole; hydrogenchloride; methanol; sodium tetrahydroborate; n-butyllithium; palladium 10% on activated carbon; hydrogen; acetic anhydride; diisopropylamine;
In
tetrahydrofuran; ethanol; hexane; N,N-dimethyl-formamide;
