929557-11-9

Upstream product

• 15097-38-8 (carbobenzyloxymethylene)triphenylphosphorane 
• 929557-09-5 benzyl 2-(1,4-dioxaspiro[4,5]decan-8-ylidene)acetate 
• 4746-97-8 cyclohexanedione monoethylene ketal 
• 929557-10-8 benzyl 2-(1,4-dioxaspiro[4,5]decan-8-yl)acetate 

Downstream Products

• 956596-75-1 C₁₅H₁₈O₄ 
• 929557-13-1 benzyl 2-(cis-4-hydroxycyclohexyl)acetate 
• 1420039-60-6 dibenzyl 3-(4-((tert-butyldimethylsilyl)oxy)benzyl)-2-(cis-4-((tert-butyldimethylsilyl)oxy)cyclohexyl)-2-hydroxysuccinate 
• 1420039-62-8 3-(4-((tert-butyldimethylsilyl)oxy)benzyl)-2-(cis-4-((tert-butyldimethylsilyl)oxy)cyclohexyl)-2-hydroxysuccinic acid 
• 1420039-64-0 3-(4-((tert-butyldimethylsilyl)oxy)benzyl)-4-(cis-4-((tert-butyldimethylsilyl)oxy)cyclohexyl)furan-2,5-dione 
• 1420039-66-2 dimethyl 2-(4-((tert-butyldimethylsilyl)oxy)benzyl)-3-(cis-4-((tert-butyldimethylsilyl)oxy)cyclohexyl)maleate 
• 1420039-68-4 dimethyl 2-(cis-4-((tert-butyldimethylsilyl)oxy)cyclohexyl)-3-(4-hydroxybenzyl)maleate 
• 1420039-70-8 dimethyl 2-(4-(2-((tert-butoxycarbonyl)amino)ethoxy)benzyl)-3-(cis-4-((tert-butyldimethylsilyl)oxy)cyclohexyl)maleate 
• 1420039-72-0 dimethyl 2-(4-(2-aminoethoxy)benzyl)-3-(cis-4-hydroxycyclohexyl)maleate 
• 929557-14-2 benzyl 2-(cis-4-((tert-butyldimethylsilyl)oxy)cyclohexyl)acetate 
• 1420039-29-7 3-(cis-4-((tert-butyldimethylsilyl)oxy)cyclohexyl)-4-cyclopentylfuran-2,5-dione 
• 1420039-31-1 3-cyclopentyl-4-(cis-4-hydroxycyclohexyl)furan-2,5-dione 
• 1420039-33-3 benzyl 2-(cis-4-((tert-butyldimethylsilyl)oxy)cyclohexyl)-2-hydroxyacetate 
• 1420039-36-6 benzyl 2-(cis-4-((tert-butyldimethylsilyl)oxy)cyclohexyl)-2-oxoacetate 

Relevant academic research and scientific papers

NDM INHIBITOR

An objective of the present invention is to provide a novel NDM (New Delhi metallo-β-lactamase) inhibitor that functions as a drug for restoring the antibacterial activity of β-lactam antibiotics that have been inactivated as a result of decomposition by NDM. According to the present invention, there is provided an NDM inhibitor contains a compound represented by general formula (I):

Metallo-beta-lactamase inhibitors

A new metallo-β-lactamase inhibitor which acts as a medicament for inhibiting the inactivation of β-lactam antibiotics and recovering anti-bacterial activities is disclosed. The maleic acid derivatives having the general formula (I) have metallo-β-lactamase inhibiting activities. It is possible to recover the anti-bacterial activities of β-lactam antibiotics against metallo-β-lactamase producing bacteria by combining the compound of the general formula (I) with β-lactam antibiotics.

Antibiotic-Bound Poly(Caprolactone) Polymer

This invention is the design and synthesis of a caprolactone monomer which bears a pendant protected carboxyl group. This monomer has been copolymerized with caprolactone in varying ratios. After polymerization, the protecting group can be removed and an antibiotic can be attached as a new pendant group. The bioactivity of the antibiotic-bound poly(caprolactone) polymer is described.