2-bromo-4-(4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,11-heptadecafluoroundecyl)-1-isopropoxybenzene

Base Information

• Chemical Name: 2-bromo-4-(4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,11-heptadecafluoroundecyl)-1-isopropoxybenzene
• CAS No.: 849354-63-8
• Molecular Formula: C₂₀H₁₆BrF₁₇O
• Molecular Weight: 675.223
• Mol file: 849354-63-8.mol

Synonyms:2-bromo-4-(4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,11-heptadecafluoroundecyl)-1-isopropoxybenzene

Chemical Property of 2-bromo-4-(4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,11-heptadecafluoroundecyl)-1-isopropoxybenzene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-bromo-4-(4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,11-heptadecafluoroundecyl)-1-isopropoxybenzene

There total 6 articles about 2-bromo-4-(4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,11-heptadecafluoroundecyl)-1-isopropoxybenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.4%

1-(4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,11-heptadecafluoroundecyl)-4-isopropoxybenzene (849354-62-7) → 2-bromo-4-(4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,11-heptadecafluoroundecyl)-1-isopropoxybenzene (849354-63-8)

Guidance literature:

With bromine; acetic acid; In dichloromethane; at 20 ℃; for 2h;

DOI:10.1021/jo048001n

Reference yield:

Estragole (140-67-0) → 2-bromo-4-(4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,11-heptadecafluoroundecyl)-1-isopropoxybenzene (849354-63-8)

Guidance literature:

Multi-step reaction with 5 steps

1: 64 percent / Me₃Al / Pd(PPh₃)4 / CH₂Cl₂; hexane / 24 h / 20 °C

2: 80.8 percent / tributyltin hydride; AIBN / benzene / 12 h / Heating

3: 87.7 percent / BBr₃*Me₂S / 1,2-dichloro-ethane / 12 h / Heating

4: 93.8 percent / sodium hydride / tetrahydrofuran; dimethylformamide / 16 h / 20 °C

5: 94.4 percent / acetic acid; bromine / CH₂Cl₂ / 2 h / 20 °C

With boron tribromide-dimethyl sulfide complex; 2,2'-azobis(isobutyronitrile); bromine; trimethylaluminum; tri-n-butyl-tin hydride; sodium hydride; acetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; hexane; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide; benzene;

DOI:10.1021/jo048001n

Reference yield:

1-iodoheptadecafluorooctane (507-63-1) → 2-bromo-4-(4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,11-heptadecafluoroundecyl)-1-isopropoxybenzene (849354-63-8)

Guidance literature:

Multi-step reaction with 5 steps

1: 64 percent / Me₃Al / Pd(PPh₃)4 / CH₂Cl₂; hexane / 24 h / 20 °C

2: 80.8 percent / tributyltin hydride; AIBN / benzene / 12 h / Heating

3: 87.7 percent / BBr₃*Me₂S / 1,2-dichloro-ethane / 12 h / Heating

4: 93.8 percent / sodium hydride / tetrahydrofuran; dimethylformamide / 16 h / 20 °C

5: 94.4 percent / acetic acid; bromine / CH₂Cl₂ / 2 h / 20 °C

With boron tribromide-dimethyl sulfide complex; 2,2'-azobis(isobutyronitrile); bromine; trimethylaluminum; tri-n-butyl-tin hydride; sodium hydride; acetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; hexane; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide; benzene;

DOI:10.1021/jo048001n

upstream raw materials:

1-(4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,11-heptadecafluoroundecyl)-4-isopropoxybenzene

1-(4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,11-heptadecafluoroundecyl)-4-methoxybenzene

1-(4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,11-heptadecafluoro-3-iodoundecyl)-4-methoxybenzene

Estragole