5-(((1-methyl-5-oxo-1,2,3,5-tetrahydroimidazo[1,2-c]pyrimidin-7-yl)oxy)methyl)-2-((5-(trifluoromethyl)pyridin-2-yl)oxy)benzonitrile trifluoroacetic acid salt

Base Information

Chemical Name:5-(((1-methyl-5-oxo-1,2,3,5-tetrahydroimidazo[1,2-c]pyrimidin-7-yl)oxy)methyl)-2-((5-(trifluoromethyl)pyridin-2-yl)oxy)benzonitrile trifluoroacetic acid salt
CAS No.:1421431-92-6
Molecular Formula:C₂HF₃O₂*C₂₁H₁₆F₃N₅O₃
Molecular Weight:557.409
Hs Code.:

5-(((1-methyl-5-oxo-1,2,3,5-tetrahydroimidazo[1,2-c]pyrimidin-7-yl)oxy)methyl)-2-((5-(trifluoromethyl)pyridin-2-yl)oxy)benzonitrile trifluoroacetic acid salt

Synonyms:5-(((1-methyl-5-oxo-1,2,3,5-tetrahydroimidazo[1,2-c]pyrimidin-7-yl)oxy)methyl)-2-((5-(trifluoromethyl)pyridin-2-yl)oxy)benzonitrile trifluoroacetic acid salt

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Chemical Property of 5-(((1-methyl-5-oxo-1,2,3,5-tetrahydroimidazo[1,2-c]pyrimidin-7-yl)oxy)methyl)-2-((5-(trifluoromethyl)pyridin-2-yl)oxy)benzonitrile trifluoroacetic acid salt

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Technology Process of 5-(((1-methyl-5-oxo-1,2,3,5-tetrahydroimidazo[1,2-c]pyrimidin-7-yl)oxy)methyl)-2-((5-(trifluoromethyl)pyridin-2-yl)oxy)benzonitrile trifluoroacetic acid salt

There total 5 articles about 5-(((1-methyl-5-oxo-1,2,3,5-tetrahydroimidazo[1,2-c]pyrimidin-7-yl)oxy)methyl)-2-((5-(trifluoromethyl)pyridin-2-yl)oxy)benzonitrile trifluoroacetic acid salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1369255-16-2
5-(hydroxymethyl)-2-((5-(trifluoromethyl)pyridin-2-yl)oxy)benzonitrile

: 1421434-99-2
7-chloro-1-methyl-2,3-dihydroimidazo[1,2-c]pyrimidin-5(1H)-one trifluoroacetic acid salt

: 1421431-92-6
5-(((1-methyl-5-oxo-1,2,3,5-tetrahydroimidazo[1,2-c]pyrimidin-7-yl)oxy)methyl)-2-((5-(trifluoromethyl)pyridin-2-yl)oxy)benzonitrile trifluoroacetic acid salt

Guidance literature:: With potassium tert-butylate; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

Reference yield:

: 611-20-1
salicylonitrile

: 1421431-92-6
5-(((1-methyl-5-oxo-1,2,3,5-tetrahydroimidazo[1,2-c]pyrimidin-7-yl)oxy)methyl)-2-((5-(trifluoromethyl)pyridin-2-yl)oxy)benzonitrile trifluoroacetic acid salt

Guidance literature:: Multi-step reaction with 5 steps

1.1: trifluorormethanesulfonic acid / acetonitrile / 0.33 h / 0 °C

1.2: 20 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / Reflux

3.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 72 h / 100 °C / 7500.75 Torr / Autoclave

4.1: lithium aluminium tetrahydride / tetrahydrofuran / -78 °C

5.1: potassium tert-butylate / N,N-dimethyl-formamide / 0.5 h / 20 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; lithium aluminium tetrahydride; trifluorormethanesulfonic acid; potassium tert-butylate; potassium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 685103-95-1
2-hydroxy-5-iodobenzonitrile

: 1421431-92-6
5-(((1-methyl-5-oxo-1,2,3,5-tetrahydroimidazo[1,2-c]pyrimidin-7-yl)oxy)methyl)-2-((5-(trifluoromethyl)pyridin-2-yl)oxy)benzonitrile trifluoroacetic acid salt

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / N,N-dimethyl-formamide / Reflux

2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 72 h / 100 °C / 7500.75 Torr / Autoclave

3: lithium aluminium tetrahydride / tetrahydrofuran / -78 °C

4: potassium tert-butylate / N,N-dimethyl-formamide / 0.5 h / 20 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; lithium aluminium tetrahydride; potassium tert-butylate; potassium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide;