(2S,3R,4S)-2-{[(4-morpholinylcarbonyl)-Z-dehydrophenylalanyl-L-histidyl]amino}-1-cyclohexyl-3,4-dihydroxy-6-methylheptane

Base Information

Chemical Name:(2S,3R,4S)-2-{[(4-morpholinylcarbonyl)-Z-dehydrophenylalanyl-L-histidyl]amino}-1-cyclohexyl-3,4-dihydroxy-6-methylheptane
CAS No.:116129-78-3
Molecular Formula:C₃₄H₅₀N₆O₆
Molecular Weight:638.808
Hs Code.:

Synonyms:(2S,3R,4S)-2-{[(4-morpholinylcarbonyl)-Z-dehydrophenylalanyl-L-histidyl]amino}-1-cyclohexyl-3,4-dihydroxy-6-methylheptane

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Chemical Property of (2S,3R,4S)-2-{[(4-morpholinylcarbonyl)-Z-dehydrophenylalanyl-L-histidyl]amino}-1-cyclohexyl-3,4-dihydroxy-6-methylheptane

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Technology Process of (2S,3R,4S)-2-{[(4-morpholinylcarbonyl)-Z-dehydrophenylalanyl-L-histidyl]amino}-1-cyclohexyl-3,4-dihydroxy-6-methylheptane

There total 6 articles about (2S,3R,4S)-2-{[(4-morpholinylcarbonyl)-Z-dehydrophenylalanyl-L-histidyl]amino}-1-cyclohexyl-3,4-dihydroxy-6-methylheptane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 116129-82-9
(Z)-4-benzylidene-2-(4-morpholinylcarbonyl)oxazolin-5-one

: 104882-47-5
(S)-2-Amino-N-((1S,2R,3S)-1-cyclohexylmethyl-2,3-dihydroxy-5-methyl-hexyl)-3-(1H-imidazol-4-yl)-propionamide; hydrochloride

: 116129-78-3
(2S,3R,4S)-2-{[(4-morpholinylcarbonyl)-Z-dehydrophenylalanyl-L-histidyl]amino}-1-cyclohexyl-3,4-dihydroxy-6-methylheptane

Guidance literature:: With triethylamine; In N,N-dimethyl-formamide; Ambient temperature;
DOI:10.1021/jm00120a006

Reference yield:

: 15159-40-7
4-morpholinocarbonyl chloride

: 116129-78-3
(2S,3R,4S)-2-{[(4-morpholinylcarbonyl)-Z-dehydrophenylalanyl-L-histidyl]amino}-1-cyclohexyl-3,4-dihydroxy-6-methylheptane

Guidance literature:: Multi-step reaction with 4 steps

1: 83 percent / triethylamine / CH₂Cl₂ / Ambient temperature

2: NaOH / tetrahydrofuran; H₂O / 1 h / Ambient temperature

3: 0.22 g / Ac₂O / 72 h

4: 60 percent / triethylamine / dimethylformamide / Ambient temperature

With sodium hydroxide; acetic anhydride; triethylamine; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm00120a006

Reference yield:

: 116129-92-1
methyl (2S,3S)-2-amino-3-hydroxy-3-phenylpropanoate

: 116129-78-3
(2S,3R,4S)-2-{[(4-morpholinylcarbonyl)-Z-dehydrophenylalanyl-L-histidyl]amino}-1-cyclohexyl-3,4-dihydroxy-6-methylheptane

Guidance literature:: Multi-step reaction with 4 steps

1: 83 percent / triethylamine / CH₂Cl₂ / Ambient temperature

2: NaOH / tetrahydrofuran; H₂O / 1 h / Ambient temperature

3: 0.22 g / Ac₂O / 72 h

4: 60 percent / triethylamine / dimethylformamide / Ambient temperature

With sodium hydroxide; acetic anhydride; triethylamine; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm00120a006