GSK2879552

Base Information

Chemical Name:GSK2879552
CAS No.:1401966-69-5
Molecular Formula:C₂₃H₂₈N₂O₂
Molecular Weight:364.488
Hs Code.:
Mol file:1401966-69-5.mol

Synonyms:4-((4-((((1R,2S)-2-phenylcyclopropyl)amino)methyl)piperidin-1-yl)methyl)benzoic acid

Suppliers and Price of GSK2879552

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

DC Chemicals
GSK2879552 >98%
100 mg
$ 550.00

DC Chemicals
GSK2879552 >98%
250 mg
$ 1000.00

Crysdot
GSK2879552 98+%
50mg
$ 718.00

Crysdot
GSK2879552 98+%
25mg
$ 399.00

ChemScene
GSK2879552 99.94%
10mg
$ 140.00

ChemScene
GSK2879552 99.94%
5mg
$ 88.00

ChemScene
GSK2879552 99.94%
50mg
$ 450.00

ChemScene
GSK2879552 99.94%
100mg
$ 850.00

Chemenu
4-((4-((((1R,2S)-2-phenylcyclopropyl)amino)methyl)piperidin-1-yl)methyl)benzoicacid 98%
100mg
$ 888.00

Cayman Chemical
GSK2879552 ≥98%
5mg
$ 88.00

Total 19 raw suppliers

Chemical Property of GSK2879552

Chemical Property:

Boiling Point:534.2±50.0 °C(Predicted)
PKA:4.03±0.10(Predicted)
Density:1.20±0.1 g/cm3(Predicted)
Storage Temp.:-20°C
Solubility.:Soluble in DMSO (up to 25 mg/ml) or in Water (up to at least 25 mg/ml)

Purity/Quality:

99%, ^*data from raw suppliers

GSK2879552 >98% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Description GSK2879552 (1401966-65-5, free base) is potent, selective, and irreversible inhibitor of Lysine Demethylase 1 (LSD1) via covalent modification of the LSD1 cofactor FAD (Ki = 1.7 μM). It is selective for LSD1 over the closely related LSD2, MAO-A, MAO-B, and the FAD dependent enzymes D-amino acid oxidase and glutathione reductase. Tested against a panel of 165 cancer cell lines, GSK2879552 inhibited the proliferation of 9 small cell lung carcinoma lines and 20 AML cell lines.

Technology Process of GSK2879552

There total 6 articles about GSK2879552 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.8%

: tert-butyl 4-((4-((((1R,2S)-2-phenylcyclopropyl)amino)methyl)piperidin-1-yl)methyl)benzoate

: 1401966-69-5
4-((4-((((1R,2S)-2-phenylcyclopropyl)amino)methyl)piperidin-1-yl)methyl)benzoic acid

Guidance literature:: With hydrogenchloride; at 89 ℃; for 2h;

Reference yield:

: 1401966-70-8
tert-butyl 4-((4-(hydroxymethyl)piperidin-1-yl)methyl)benzoate

: 1401966-69-5
4-((4-((((1R,2S)-2-phenylcyclopropyl)amino)methyl)piperidin-1-yl)methyl)benzoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 3 h / -60 °C

1.2: -60 - 20 °C

2.1: methanol / 0.08 h / Reflux

2.2: 1 h / 20 °C

3.1: hydrogenchloride / 2 h / 89 °C

With hydrogenchloride; oxalyl dichloride; dimethyl sulfoxide; In methanol; dichloromethane;

Reference yield:

: 1401966-71-9
tert-butyl 4-((4-formylpiperidine-1-yl)methyl)benzoate

: 1401966-69-5
4-((4-((((1R,2S)-2-phenylcyclopropyl)amino)methyl)piperidin-1-yl)methyl)benzoic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: methanol / 0.08 h / Reflux

1.2: 1 h / 20 °C

2.1: hydrogenchloride / 2 h / 89 °C

With hydrogenchloride; In methanol;