diphenyl 1-<amino>-2-(4-amidinophenyl)ethanephosphonate

Base Information

Chemical Name:diphenyl 1-<amino>-2-(4-amidinophenyl)ethanephosphonate
CAS No.:198902-77-1
Molecular Formula:C₄₀H₄₆N₅O₇P
Molecular Weight:739.808
Hs Code.:

diphenyl 1-<<N-(tert-butyloxycarbonyl)-D-phenylalanyl-L-prolyl>amino>-2-(4-amidinophenyl)ethanephosphonate

Synonyms:diphenyl 1-<amino>-2-(4-amidinophenyl)ethanephosphonate

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Chemical Property of diphenyl 1-<amino>-2-(4-amidinophenyl)ethanephosphonate

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Technology Process of diphenyl 1-<amino>-2-(4-amidinophenyl)ethanephosphonate

There total 10 articles about diphenyl 1-<amino>-2-(4-amidinophenyl)ethanephosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 38675-10-4
N-[(1,1-dimethylethoxy)carbonyl]-D-phenylalanyl-L-proline

: diphenyl 1-amino-2-(4-amidinophenyl)ethanephosphonate dihydrochloride

: 198902-77-1
diphenyl 1-<amino>-2-(4-amidinophenyl)ethanephosphonate

Guidance literature:: With 1,1'-carbonyldiimidazole; In N,N-dimethyl-formamide; a) 0 deg C, 2 h, b) RT, 48 h;
DOI:10.1021/jm00028a004

Reference yield:

: 101-02-0
triphenyl phosphite

: 198902-77-1
diphenyl 1-<amino>-2-(4-amidinophenyl)ethanephosphonate

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) toluene, reflux, 1 h, 2.) AcOH, 80 deg C, 2 h

2: HCl(g) / CHCl₃ / 48 h / 5 °C

3: methanolic NH₃, NH₄Cl / 24 h / Ambient temperature

4: 90 percent / H₂, HCl / 5percent Pd/C / methanol

5: 59 percent / CDI / dimethylformamide / a) 0 deg C, 2 h, b) RT, 48 h

With hydrogenchloride; ammonia; hydrogen; ammonium chloride; 1,1'-carbonyldiimidazole; palladium on activated charcoal; In methanol; chloroform; N,N-dimethyl-formamide;
DOI:10.1021/jm00028a004

Reference yield:

: 18942-49-9
Boc-D-Phe-OH

: 198902-77-1
diphenyl 1-<amino>-2-(4-amidinophenyl)ethanephosphonate

Guidance literature:: Multi-step reaction with 3 steps

1: 83 percent / DCC

2: 85 percent / H₂ / 5percent Pd/C / methanol

3: 59 percent / CDI / dimethylformamide / a) 0 deg C, 2 h, b) RT, 48 h

With hydrogen; dicyclohexyl-carbodiimide; 1,1'-carbonyldiimidazole; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00028a004