2,6-dichloro-N-(2-hydroxy-2-phenylethyl)-N-methylnicotinamide

Base Information

• Chemical Name: 2,6-dichloro-N-(2-hydroxy-2-phenylethyl)-N-methylnicotinamide
• CAS No.: 1255701-18-8
• Molecular Formula: C₁₅H₁₄Cl₂N₂O₂
• Molecular Weight: 325.194
• Mol file: 1255701-18-8.mol

Synonyms:2,6-dichloro-N-(2-hydroxy-2-phenylethyl)-N-methylnicotinamide

Chemical Property of 2,6-dichloro-N-(2-hydroxy-2-phenylethyl)-N-methylnicotinamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,6-dichloro-N-(2-hydroxy-2-phenylethyl)-N-methylnicotinamide

There total 1 articles about 2,6-dichloro-N-(2-hydroxy-2-phenylethyl)-N-methylnicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-(methylamino)-1-phenylethanol (68579-60-2,6589-55-5) + 2,6-dichloronicotinoyl chloride (58584-83-1) → 2,6-dichloro-N-(2-hydroxy-2-phenylethyl)-N-methylnicotinamide (1255701-18-8)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 20 ℃; for 16h;

Reference yield: 54.0%

2,6-dichloro-N-(2-hydroxy-2-phenylethyl)-N-methylnicotinamide (1255701-18-8) → 8-chloro-4-methyl-2-phenyl-3,4-dihydropyrido [3,2-f][1,4]oxazepin-5(2H)-one (1255701-17-7)

Guidance literature:

With sodium hydride; In tetrahydrofuran; at 20 ℃; Cooling with ice-water;

Reference yield:

2,6-dichloro-N-(2-hydroxy-2-phenylethyl)-N-methylnicotinamide (1255701-18-8) → 4-methyl-8-(4-(3-methyl-1,2,4-oxadiazol-5-yl)phenylamino)-2-phenyl-3,4-dihydropyrido[3,2-f][1,4]oxazepin-5(2H)-one (1255700-20-9)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydride / tetrahydrofuran / 20 °C / Cooling with ice-water

2: caesium carbonate / palladium diacetate; CyJohnPhos / 1,2-dimethoxyethane / 1 h / 100 °C / Microwave reactor

With sodium hydride; caesium carbonate; palladium diacetate; CyJohnPhos; In tetrahydrofuran; 1,2-dimethoxyethane;

upstream raw materials:

2-(methylamino)-1-phenylethanol

2,6-dichloronicotinoyl chloride

Downstream raw materials:

8-chloro-4-methyl-2-phenyl-3,4-dihydropyrido [3,2-f][1,4]oxazepin-5(2H)-one

4-methyl-8-(4-(3-methyl-1,2,4-oxadiazol-5-yl)phenylamino)-2-phenyl-3,4-dihydropyrido[3,2-f][1,4]oxazepin-5(2H)-one