DL-ALPHA-(METHYLAMINOMETHYL)BENZYL ALCOHOL

Base Information

• Chemical Name: DL-ALPHA-(METHYLAMINOMETHYL)BENZYL ALCOHOL
• CAS No.: 68579-60-2
• Molecular Formula: C9H14NO+
• Molecular Weight: 151.208
• Mol file: 68579-60-2.mol

Synonyms:DL-alpha-(Methylaminomethyl)benzyl alcohol;DL-α-(METHYLAMINOMETHYL)BENZYL ALCOHOL;

Chemical Property of DL-ALPHA-(METHYLAMINOMETHYL)BENZYL ALCOHOL

Chemical Property:

• Vapor Pressure: 0.0165mmHg at 25°C
• Melting Point: 74-76oC(lit.)
• Refractive Index: 1.5380 (estimate)
• Boiling Point: 244.1°C at 760 mmHg
• Flash Point: 96.3°C
• PSA: 32.26000
• Density: 1.0406 (rough estimate)
• LogP: 1.33030
• Storage Temp.: -20°C, Inert atmosphere
• Solubility.: Chloroform (Slightly), Methanol (Slightly)

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 20/22
• Safety Statements: 36

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-(Methylamino)-1-phenylethanol is a reagent used in the synthesis of novel hydrazine inhibitors for human vascular adhesion protein-1.

Technology Process of DL-ALPHA-(METHYLAMINOMETHYL)BENZYL ALCOHOL

There total 47 articles about DL-ALPHA-(METHYLAMINOMETHYL)BENZYL ALCOHOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

N-(β-Hydroxyphenaethyl)-N-methyl-carbaminsaeure-(t-butyl)ester (77184-09-9) → 2-(methylamino)-1-phenylethanol (68579-60-2,6589-55-5)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 12h;

DOI:10.1016/S0040-4020(97)00166-X

Reference yield: 97.0%

2,2,2-trifluoro-N-methyl-N-(2-oxo-2-phenylethyl)acetamide (57052-65-0) → 2-(methylamino)-1-phenylethanol (68579-60-2,6589-55-5)

Guidance literature:

With sodium tetrahydroborate; In ethanol; for 12h;

DOI:10.1021/jo00196a001

Reference yield: 95.6%

N-methyl-2-hydroxy-2-phenylethanamide (65645-88-7,89843-35-6,96392-41-5,2019-72-9) → 2-(methylamino)-1-phenylethanol (68579-60-2,6589-55-5)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 70 - 75 ℃; for 8h;

upstream raw materials:

styrene oxide

methylamine

formaldehyd

2-nitro-1-phenylethan-1-ol

Downstream raw materials:

N-methyl (S)-2-hydroxy-2-phenylethylamine

(-)-Halostachine

2,2,3,3,9-pentamethyl-7-phenyl-1,4,6-trioxa-9-aza-5λ⁵-phospha-spiro[4.4]nonane

3'-methyl-5'-phenyl-2λ⁵-spiro[benzo[1,3,2]dioxaphosphole-2,2'-[1,3,2]oxazaphospholidine]

Refernces

• 1、 Buev, Evgeny M.,Moshkin, Vladimir S.,Smorodina, Anastasia A.,Sosnovskikh, Vyacheslav Y.. "5-Aryloxazolidines as Reagents for Double Alkylation of Arenes: A Novel Synthesis of 4-Aryltetrahydroisoquinolines". . p. 15307 - 15317. Retrieved 2021/10/20.
• 2、 -. "Method for synthesizing N-methylphenethyl ethanolamine and hydrochloride thereof". . . Retrieved 2017/08/30.