C₂₂H₂₁FN₂O₄S

Base Information

Chemical Name:C₂₂H₂₁FN₂O₄S
CAS No.:1374229-60-3
Molecular Formula:C₂₂H₂₁FN₂O₄S
Molecular Weight:428.484
Hs Code.:

C<sub>22</sub>H<sub>21</sub>FN<sub>2</sub>O<sub>4</sub>S

Synonyms:C₂₂H₂₁FN₂O₄S

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of C₂₂H₂₁FN₂O₄S

Chemical Property:

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Technology Process of C₂₂H₂₁FN₂O₄S

There total 13 articles about C₂₂H₂₁FN₂O₄S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 1374232-98-0
C₂₁H₁₈FNO₅S

: 593-51-1
methylamine hydrochloride

: 1374229-60-3
C₂₂H₂₁FN₂O₄S

Guidance literature:: C₂₁H₁₈FNO₅S; With HATU; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

methylamine hydrochloride; With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 0.333333h;

Reference yield:

: 536-90-3,918666-97-4
m-Anisidine

: 1374229-60-3
C₂₂H₂₁FN₂O₄S

Guidance literature:: Multi-step reaction with 13 steps

1.1: copper(l) iodide; copper diacetate / water / 48 h / 100 °C

2.1: polyphosphoric acid / 3 h / 90 °C

3.1: triethylamine / dichloromethane / 3 h / 0 - 20 °C

4.1: n-butyllithium / tetrahydrofuran; hexane / 2 h / 0 °C

4.2: 0 - 20 °C

5.1: diethylzinc / hexane; toluene / 0 - 20 °C

6.1: N-Bromosuccinimide / dichloromethane / 1 h / 0 - 20 °C

7.1: boron tribromide / dichloromethane / 1 h / -20 - 0 °C

7.2: Cooling with ice

8.1: triethylamine / dmap / tetrahydrofuran / 10 h / 0 - 20 °C

9.1: piperidine / bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tri-tert-butyl phosphine / N,N-dimethyl-formamide / 80 °C / Inert atmosphere

10.1: hydrogenchloride / 1,4-dioxane / 2 h / 20 °C

11.1: sodium acetate; potassium carbonate / copper dichloride; palladium dichloride / 20 °C

12.1: lithium hydroxide / tetrahydrofuran; methanol / 2 h / 70 °C

12.2: 20 °C

13.1: HATU / N,N-dimethyl-formamide / 0.5 h / 20 °C

13.2: 0.33 h / 20 °C

With piperidine; hydrogenchloride; N-Bromosuccinimide; n-butyllithium; diethylzinc; sodium acetate; boron tribromide; potassium carbonate; triethylamine; HATU; lithium hydroxide; dmap; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tri-tert-butyl phosphine; copper diacetate; copper dichloride; palladium dichloride; In tetrahydrofuran; 1,4-dioxane; methanol; hexane; dichloromethane; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 879-56-1
7-Methoxy-2,3-dihydro-1H-quinolin-4-one

: 1374229-60-3
C₂₂H₂₁FN₂O₄S

Guidance literature:: Multi-step reaction with 11 steps

1.1: triethylamine / dichloromethane / 3 h / 0 - 20 °C

2.1: n-butyllithium / tetrahydrofuran; hexane / 2 h / 0 °C

2.2: 0 - 20 °C

3.1: diethylzinc / hexane; toluene / 0 - 20 °C

4.1: N-Bromosuccinimide / dichloromethane / 1 h / 0 - 20 °C

5.1: boron tribromide / dichloromethane / 1 h / -20 - 0 °C

5.2: Cooling with ice

6.1: triethylamine / dmap / tetrahydrofuran / 10 h / 0 - 20 °C

7.1: piperidine / bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tri-tert-butyl phosphine / N,N-dimethyl-formamide / 80 °C / Inert atmosphere

8.1: hydrogenchloride / 1,4-dioxane / 2 h / 20 °C

9.1: sodium acetate; potassium carbonate / copper dichloride; palladium dichloride / 20 °C

10.1: lithium hydroxide / tetrahydrofuran; methanol / 2 h / 70 °C

10.2: 20 °C

11.1: HATU / N,N-dimethyl-formamide / 0.5 h / 20 °C

11.2: 0.33 h / 20 °C

With piperidine; hydrogenchloride; N-Bromosuccinimide; n-butyllithium; diethylzinc; sodium acetate; boron tribromide; potassium carbonate; triethylamine; HATU; lithium hydroxide; dmap; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tri-tert-butyl phosphine; copper dichloride; palladium dichloride; In tetrahydrofuran; 1,4-dioxane; methanol; hexane; dichloromethane; N,N-dimethyl-formamide; toluene;